2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist

A peptide corresponding to a proteinase-activated receptor 2 (PAR(2))-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH(2), was assessed for PAR(2)-dependent and -independent biological activities. 2-Furoyl-LIGRLO-NH(2) was equally effective to and 10 to 25 times mo...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of pharmacology and experimental therapeutics Vol. 309; no. 3; p. 1124
Main Authors:	McGuire, John J, Saifeddine, Mahmoud, Triggle, Chris R, Sun, Kimberly, Hollenberg, Morley D
Format:	Journal Article
Language:	English
Published:	United States 01-06-2004
Subjects:	Amides - pharmacology Animals Aorta - drug effects Aorta - physiology Electrophysiology Femoral Artery Humans Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Mice Mice, Inbred C57BL Oligopeptides - pharmacology Peptides - pharmacology Rats Rats, Sprague-Dawley Receptor, PAR-2 - agonists Receptor, PAR-2 - metabolism Vascular Resistance - drug effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!