Congenital Leishmaniasis in a Newborn Infant Whose Mother was Coinfected With Leishmaniasis and HIV

In utero transmission of Leishmania infantum is the putative mechanism of congenital leishmaniasis. However, this hypothesis is based on limited research. In addition, the consequences for infant newborn development remain to be clarified by additional data. We report here the occurrence, specific m...

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Bibliographic Details
Published in:	Journal of the Pediatric Infectious Diseases Society Vol. 9; no. 2; pp. 277 - 280
Main Authors:	Argy, Nicolas, Lariven, Sylvie, Rideau, Aline, Lemoine, Anais, Bourgeois Moine, Agnès, Allal, Lahcene, Choudat, Laurence, Ravel, Christophe, Michard, Florence, Buffet, Pierre, Faye, Albert, Houze, Sandrine, Yazdanpanah, Yazdan
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 30-04-2020
Subjects:	Adult Bioengineering Brain Brain - diagnostic imaging Brain - pathology Coinfection Female Fetal Growth Retardation Gynecology and obstetrics HIV Infections HIV Infections - complications Human health and pathology Humans Imaging Infant, Newborn Infectious diseases Leishmania infantum Leishmania infantum - isolation & purification Leishmaniasis Leishmaniasis - complications Leishmaniasis - congenital Leishmaniasis - parasitology Life Sciences Magnetic Resonance Imaging Microbiology and Parasitology Parasite Load Pediatrics Pregnancy Pregnancy Complications, Infectious transplacental Leishmania–HIV coinfection congenital leishmaniasis amphotericin B failure Transplacental Leishmaniasis Congenital Amphotericin B failure
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Summary:	In utero transmission of Leishmania infantum is the putative mechanism of congenital leishmaniasis. However, this hypothesis is based on limited research. In addition, the consequences for infant newborn development remain to be clarified by additional data. We report here the occurrence, specific management, and monitoring of congenital leishmaniasis in a newborn infant whose mother was coinfected with leishmaniasis and human immunodeficiency virus; transplacental transmission, confirmed by overt clinical disease at birth, was documented, which provides, to our knowledge, the first evidence of hepatic and neurologic impairment in an infant with congenital visceral leishmaniasis.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	2048-7207 2048-7193 2048-7207
DOI:	10.1093/jpids/piz055