Characterization of factors affecting the release of low-solubility drug from prolonged release tablets

Diclofenac sodium (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid monosodium salt) was investigated as a low-solubility drug and Naklofen ® retard prolonged release tablets, containing 100 mg of diclofenac sodium as a prolonged release lipophilic matrix system using factorial design approach. First...

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Bibliographic Details
Published in:	Analytica chimica acta Vol. 502; no. 1; pp. 107 - 113
Main Authors:	Kincl, M, Vrečer, F, Veber, M
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 23-01-2004 Elsevier
Subjects:	Analysis Biological and medical sciences Fractional factorial designs General pharmacology Ionic strengths Medical sciences Pharmacology. Drug treatments Prolonged release tablets Two-level designs pH Fractional factorial designs Ionic strengths Two-level designs Prolonged release tablets Drug Stirring Solubility Dissolution Diclofenac Sodium Ionic strength Aqueous medium Tablet Factorial design Release
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