Eculizumab for bevacizumab induced thrombotic microangiopathy: A case report

Bevacizumab is a monoclonal human antibody that is effective in the treatment of cancers in both adults and children due to inhibition of vascular endothelial growth factor. Throbotic microangiopathy (TMA) is well-known complication of bevacizumab. Herein, we report a case of desmoplastic small roun...

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Bibliographic Details
Published in:	Pediatric hematology oncology journal Vol. 7; no. 4; pp. 169 - 172
Main Authors:	İnözü, Mihriban, Özlü, Sare Gülfem, Özyörük, Derya, Kiremitçi, Saba, Çakmakçı, Selma, Avcı, Begüm, Özdemir, Sonay İncesoy, Bayrakçı, Umut Selda
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2022 Elsevier
Subjects:	Bevacizumab Eculizumab Thrombotic microangiopathy Eculizumab Thrombotic microangiopathy Bevacizumab
Online Access:	Get full text
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Summary:	Bevacizumab is a monoclonal human antibody that is effective in the treatment of cancers in both adults and children due to inhibition of vascular endothelial growth factor. Throbotic microangiopathy (TMA) is well-known complication of bevacizumab. Herein, we report a case of desmoplastic small round cell tumor in a 17-year-old male presenting with TMA after bevacizumab treatment. Eculizumab was administered as second line agent for treatment of thrombotic microangiopathy and partial remission was achieved. With this case report we would like to emphasize the renal effects of bevacizumab and discuss the role of eculizumab in the treatment of bevacizumab related TMA.
ISSN:	2468-1245 2468-1245
DOI:	10.1016/j.phoj.2022.08.006