Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had si...

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Bibliographic Details
Published in:	Journal of Alzheimer's disease Vol. 50; no. 4; p. 957
Main Authors:	Balietti, Marta, Giuli, Cinzia, Fattoretti, Patrizia, Fabbietti, Paolo, Postacchini, Demetrio, Conti, Fiorenzo
Format:	Journal Article
Language:	English
Published:	Netherlands 22-02-2016
Subjects:	Blood Platelets - metabolism Cognition - physiology Cognitive Behavioral Therapy Cognitive Dysfunction - blood Cognitive Dysfunction - therapy Cohort Studies Humans Mental Status Schedule Neuropsychological Tests Phospholipases A2 - blood Treatment Outcome cognitive stimulation mild cognitive impairment Blood platelets phospholipases A2
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Summary:	We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA2A.
ISSN:	1875-8908
DOI:	10.3233/JAD-150714