Lactobacilli and Klebsiella: Two Opposites in the Fight for Human Health

• Published in: Biochemistry (Moscow) Vol. 89; no. Suppl 1; pp. S71 - S89
• Main Authors: Shaposhnikov, Leonid A., Tishkov, Vladimir I., Pometun, Anastasia A.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2024; Springer Nature B.V
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Drug development; Drug resistance; Gastrointestinal system; Gastrointestinal tract; Humans; Klebsiella; Lactobacilli; Lactobacillus; Life Sciences; Limosilactobacillus reuteri; Microbiology; Nosocomial infection; Probiotics; Public health; R&D; Research & development; Review; Reviews; Side effects; Strains (organisms); antibiotic resistance; lactobacilli; Klebsiella; Limosilactobacillus reuteri
• ISSN: 0006-2979; 1608-3040
• DOI: 10.1134/S0006297924140050

The problem of antibiotic resistance is currently very acute. Numerous research and development of new antibacterial drugs are being carried out that could help cope with various infectious agents. One of the promising directions for the search for new antibacterial drugs is the search among the probiotic strains present in the human gastrointestinal tract. This review is devoted to characteristics of one of these probiotic strains that have been studied to date:
Limosilactobacillus reuteri
. The review discusses its properties, synthesis of various compounds, as well as role of this strain in modulating various systems of the human body. The review also examines key characteristics of one of the most harmful among the currently known pathogenic organisms,
Klebsiella
, which is significantly resistant to antibiotics existing in medical practice, and also poses a great threat of nosocomial infections. Discussion of characteristics of the two strains, which have opposite effects on human health, may help in creation of new effective antibacterial drugs without significant side effects.