Stabilisation of immunoconjugates by trehalose

Stable immunoconjugates were prepared in the presence of 400 mM trehalose. Their residual activity after freeze-drying, rehydration and incubation for 9 h at 40°C was 35%. Freeze-dried conjugates containing 400 mM trehalose incubated at 40°C for 4 days retained 80% of their original activity.[PUBLIC...

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Bibliographic Details
Published in:	Biotechnology letters Vol. 22; no. 5; pp. 417 - 420
Main Authors:	ESTEVES, M. I, QUINTILIO, W, SATO, R. A, RAW, I, SOARES DE ARAUJO, P, BUENO DA COSTA, M. H
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01-03-2000 Springer Nature B.V
Subjects:	Biological and medical sciences Biotechnology Cells Freeze drying Freezing Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Others trehalose Various methods and equipments Freeze drying Storage Trehalose Stabilization Rehydration Immunoconjugate Thermal stability
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Summary:	Stable immunoconjugates were prepared in the presence of 400 mM trehalose. Their residual activity after freeze-drying, rehydration and incubation for 9 h at 40°C was 35%. Freeze-dried conjugates containing 400 mM trehalose incubated at 40°C for 4 days retained 80% of their original activity.[PUBLICATION ABSTRACT]
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0141-5492 1573-6776
DOI:	10.1023/A:1005605616356