Human-relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice

Abstract Phthalates are compounds used in consumer and medical products worldwide. Phthalate exposure in women has been demonstrated by detection of phthalate metabolites in their urine and ovarian follicular fluid. High urinary phthalate burden has been associated with reduced ovarian reserve and o...

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Bibliographic Details

Published in:	Toxicological sciences Vol. 195; no. 1; pp. 42 - 52
Main Authors:	Jauregui, Estela J, McSwain, Maile, Liu, Xiaosong, Miller, Kara, Burns, Kimberlie, Craig, Zelieann R
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 29-08-2023
Subjects:	Animals Dibutyl Phthalate - toxicity Female Humans Insulin-Like Growth Factor I - genetics Mice Ovary Phthalic Acids folliculogenesis ovary insulin-like growth factor dibutyl phthalate
Online Access:	Get full text
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