Lipid/Hyaluronic Acid–Coated Doxorubicin-Fe3O4 as a Dual-Targeting Nanoparticle for Enhanced Cancer Therapy
Development of a delivery system to lower systemic toxicity and enhance doxorubicin (DOX) antitumor efficacy against multi-drug resistant (MDR) tumors is of great clinical significance. Here, lipid/hyaluronic acid (HA)–coated DOX-Fe 3 O 4 was characterized to determine its optimal safety and efficac...
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| Published in: | AAPS PharmSciTech Vol. 21; no. 6; p. 235 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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14-08-2020
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| Abstract | Development of a delivery system to lower systemic toxicity and enhance doxorubicin (DOX) antitumor efficacy against multi-drug resistant (MDR) tumors is of great clinical significance. Here, lipid/hyaluronic acid (HA)–coated DOX-Fe
3
O
4
was characterized to determine its optimal safety and efficacy on a tumor. DOX was first conjugated onto the Fe
3
O
4
NPs surface, which was subsequently coated with phosphatidylcholine (PC) lipids, which consisted of a tumor cell–targeting HA ligand, to generate a dual-targeting nanoparticle (NP). DOX-Fe
3
O
4
synthesis was validated by the Fourier-transform infrared (FT-IR) analysis results. Core-shell PC/HA@DOX-Fe
3
O
4
formation, which had an average particle size of 48.2 nm, was observed based on the transmission electron microscopy (TEM) and dynamic laser light scattering (DLS) results. The saturation magnetization value of PC/HA@DOX-Fe
3
O
4
was discovered to be 28 emu/g using vibrating-sample magnetometry. Furthermore, the designed PC/HA@DOX-Fe
3
O
4
achieved greater MCF-7/ADR cellular uptake and cytotoxicity as compared with DOX. In addition, PC/HA@DOX-Fe
3
O
4
exhibited significant DOX tumor-targeting capabilities and enhanced tumor growth inhibition activity in the xenograft MCF-7/ADR tumor-bearing nude mice following magnetic attraction and ligand-mediated targeting, with less cardiotoxicity. Therefore, PC/HA@DOX-Fe
3
O
4
is a potential candidate for MDR tumor chemotherapy.
Graphical abstract |
|---|---|
| AbstractList | Development of a delivery system to lower systemic toxicity and enhance doxorubicin (DOX) antitumor efficacy against multi-drug resistant (MDR) tumors is of great clinical significance. Here, lipid/hyaluronic acid (HA)–coated DOX-Fe
3
O
4
was characterized to determine its optimal safety and efficacy on a tumor. DOX was first conjugated onto the Fe
3
O
4
NPs surface, which was subsequently coated with phosphatidylcholine (PC) lipids, which consisted of a tumor cell–targeting HA ligand, to generate a dual-targeting nanoparticle (NP). DOX-Fe
3
O
4
synthesis was validated by the Fourier-transform infrared (FT-IR) analysis results. Core-shell PC/HA@DOX-Fe
3
O
4
formation, which had an average particle size of 48.2 nm, was observed based on the transmission electron microscopy (TEM) and dynamic laser light scattering (DLS) results. The saturation magnetization value of PC/HA@DOX-Fe
3
O
4
was discovered to be 28 emu/g using vibrating-sample magnetometry. Furthermore, the designed PC/HA@DOX-Fe
3
O
4
achieved greater MCF-7/ADR cellular uptake and cytotoxicity as compared with DOX. In addition, PC/HA@DOX-Fe
3
O
4
exhibited significant DOX tumor-targeting capabilities and enhanced tumor growth inhibition activity in the xenograft MCF-7/ADR tumor-bearing nude mice following magnetic attraction and ligand-mediated targeting, with less cardiotoxicity. Therefore, PC/HA@DOX-Fe
3
O
4
is a potential candidate for MDR tumor chemotherapy.
Graphical abstract |
| ArticleNumber | 235 |
| Author | Liang, Jinying Yang, Xue Liu, Danmeng Bai, Suping Cong, Mei Song, Yu |
| Author_xml | – sequence: 1 givenname: Jinying surname: Liang fullname: Liang, Jinying email: jinyingliangxxmu@163.com organization: School of Pharmacy, Xinxiang Medical University – sequence: 2 givenname: Xue surname: Yang fullname: Yang, Xue organization: School of Pharmacy, Xinxiang Medical University – sequence: 3 givenname: Danmeng surname: Liu fullname: Liu, Danmeng organization: School of Pharmacy, Xinxiang Medical University – sequence: 4 givenname: Mei surname: Cong fullname: Cong, Mei organization: School of Pharmacy, Xinxiang Medical University – sequence: 5 givenname: Yu surname: Song fullname: Song, Yu organization: School of Pharmacy, Xinxiang Medical University – sequence: 6 givenname: Suping surname: Bai fullname: Bai, Suping organization: School of Pharmacy, Xinxiang Medical University |
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| CitedBy_id | crossref_primary_10_3390_pharmaceutics14102092 crossref_primary_10_3390_pharmaceutics12100931 crossref_primary_10_1016_j_carbpol_2021_118491 crossref_primary_10_1016_j_drudis_2021_09_020 crossref_primary_10_1016_j_tiv_2024_105830 crossref_primary_10_3390_pharmaceutics15030771 crossref_primary_10_1557_s43578_021_00424_x crossref_primary_10_3390_pharmaceutics15061713 crossref_primary_10_1016_j_matlet_2023_134379 crossref_primary_10_1007_s40005_022_00583_x crossref_primary_10_1016_j_drup_2023_100956 crossref_primary_10_1016_j_envres_2023_116989 crossref_primary_10_1186_s12645_022_00117_y crossref_primary_10_1016_j_jddst_2021_103026 crossref_primary_10_3390_gels9020121 |
| Cites_doi | 10.1016/j.ultsonch.2017.04.025 10.1002/med.21280 10.1016/j.biomaterials.2016.01.023 10.1208/s12249-018-1157-2 10.1021/cr300068p 10.1039/C0NR00521E 10.3390/pharmaceutics11020063 10.1208/s12249-017-0792-3 10.1002/adma.201902604 10.1016/j.jconrel.2012.05.051 10.1073/pnas.1704226114 10.1007/s10557-016-6711-0 10.1039/C9TB01250H 10.1208/s12249-019-1385-0 10.1016/j.biopha.2016.03.015 10.1016/j.actbio.2018.09.006 10.1097/FPC.0b013e32833ffb56 10.1016/j.ijpharm.2017.10.023 10.1016/j.ebiom.2018.03.008 10.1159/000086183 10.1021/acs.chemrev.5b00112 10.1016/j.jconrel.2004.12.018 10.1038/nrc.2016.108 10.1016/j.actbio.2013.08.015 10.1038/s41598-019-47262-w 10.1016/j.jconrel.2014.09.020 10.1016/j.ijpharm.2017.09.071 10.1200/JCO.1997.15.3.974 10.1002/btm2.10003 10.1016/j.biotechadv.2013.03.005 10.1016/j.addr.2015.10.022 10.1016/j.critrevonc.2012.03.002 10.1016/j.ijpharm.2013.12.004 10.1016/j.colsurfb.2014.03.001 10.2147/IJN.S128525 10.2147/IJN.S213974 10.1016/j.biomaterials.2009.09.103 10.1111/1440-1681.12581 10.1016/S0378-5173(01)00936-X 10.1038/nmat1251 10.1016/j.jconrel.2014.12.030 10.1002/jemt.20849 |
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| Keywords | multi-drug resistance 0 dual-targeting nanoparticle doxorubicin-Fe cardiotoxicity hyaluronic acid |
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| References | Dora, Kushwah, Katiyar, Kumar, Pillay, Suresh (CR37) 2017; 534 Hu, Sun, Wang, Gu (CR1) 2016; 98 Pan, Li, He, Qiu, Zhou (CR4) 2016; 43 Gao, Zhang, Sun (CR16) 2012; 162 Reddy, Arias, Nicolas, Couvreur (CR18) 2012; 112 Shi, Kantoff, Wooster, Farokhzad (CR11) 2017; 17 Melguizo, Ruiz Martinez, Arias, Delgado (CR20) 2017; 18 Zhao, Chen, Liu, Li, Tang, Liu (CR41) 2015; 10 CR31 Das, Nicastri, Coluccio, Gentile, Candeloro, Cojoc (CR35) 2010; 73 Wicki, Witzigmann, Balasubramanian, Huwyler (CR10) 2015; 200 Fang, Li, Xu, Du, Wang, Shi, Gao (CR26) 2019; 14 Gupta, Poudel, Ruttala, Regmi, Pathak, Gautam (CR44) 2018; 80 Liang, Zhang, Miao, Li, Gan (CR42) 2017; 12 Ling, Priebe, Perez-Soler (CR45) 1993; 53 Luqmani (CR8) 2005; 14 Su, Chen, Xiao, Sun, Zong, Asghar (CR47) 2014; 196 McGowan, Chung, Maulik, Piotrowska, Walker, Yellon (CR3) 2017; 31 Curk, Dobnikar, Frenkel (CR28) 2017; 114 Demortiere, Panissod, Pichon, Pourroy, Guillon (CR40) 2011; 3 Zhang, Li, Pan, Liu, Ji, Sheng (CR46) 2016; 83 Patsula, Horak, Kucka, Mackova, Lobaz, Francova (CR22) 2019; 9 Anselmo, Mitragotri (CR9) 2016; 1 Muthiah, Park, Cho (CR23) 2013; 31 Qian, Chen, Wang, Ren (CR38) 2018; 19 Prabha, Raj (CR21) 2016; 80 Park, An, Hwang, Park, Noh, Kim (CR32) 2004; 3 CR15 Igartua, Saulnier, Heurtault, Pech, Proust, Pedraz (CR34) 2002; 233 Lee, Na, Bae (CR29) 2005; 103 Zafar, Fessi, Elaissari (CR17) 2014; 461 Lee, Yoo, Ling, Cho, Hyeon, Cheon (CR19) 2015; 115 Khoee, Saadatinia, Bafkary (CR43) 2017; 39 Unterweger, Dezsi, Matuszak, Janko, Poettler, Jordan (CR39) 2018; 13 Lv, Li, Tang (CR14) 2013; 9 Ding, Guo (CR36) 2013; 8 Sadighian, Rostamizadeh, Hosseini-Monfared, Hamidi (CR12) 2014; 117 Carvalho, Burgeiro, Garcia, Moreno, Carvalho, Oliveira (CR5) 2014; 34 Voon, Kue, Imae, Saw, Lee, Kiew (CR13) 2017; 534 Gupta, Poudel, Ruttala, Regmi, Pathak, Gautam (CR27) 2018; 80 Galmarini, Galmarini, Galmarini (CR2) 2012; 84 Gong, Dong, Fu, Gong, Deng, Zhang (CR25) 2019; 7 Akbarzadeh, Mikaeili, Zarghami, Mohammad, Barkhordari, Davaran (CR24) 2012; 7 Mitry, Edwards (CR6) 2016; 10 Xu, Zhang, Chen, Chen, Lin, Li (CR30) 2010; 31 Thorn, Oshiro, Marsh (CR7) 2011; 21 Chen, Zhou, Li, Duan, Hu, Liu (CR33) 2018; 30 Li, Lai, Qiu, Luo, Hu, Zheng (CR48) 2019; 20 Brady, Cella, Mo, Bonomi, Tulsky, Lloyd (CR49) 1997; 15 B Gupta (1764_CR27) 2018; 80 W Ding (1764_CR36) 2013; 8 J Liang (1764_CR42) 2017; 12 Z Su (1764_CR47) 2014; 196 J Park (1764_CR32) 2004; 3 ST Pan (1764_CR4) 2016; 43 S Khoee (1764_CR43) 2017; 39 C Li (1764_CR48) 2019; 20 X Zhao (1764_CR41) 2015; 10 YA Luqmani (1764_CR8) 2005; 14 D Galmarini (1764_CR2) 2012; 84 LH Reddy (1764_CR18) 2012; 112 1764_CR31 N Lee (1764_CR19) 2015; 115 T Gong (1764_CR25) 2019; 7 ES Lee (1764_CR29) 2005; 103 A Wicki (1764_CR10) 2015; 200 JV McGowan (1764_CR3) 2017; 31 H Unterweger (1764_CR39) 2018; 13 Q Hu (1764_CR1) 2016; 98 G Das (1764_CR35) 2010; 73 AC Anselmo (1764_CR9) 2016; 1 X Chen (1764_CR33) 2018; 30 T Curk (1764_CR28) 2017; 114 Y Zhang (1764_CR46) 2016; 83 A Akbarzadeh (1764_CR24) 2012; 7 G Prabha (1764_CR21) 2016; 80 CF Thorn (1764_CR7) 2011; 21 S Sadighian (1764_CR12) 2014; 117 Z Gao (1764_CR16) 2012; 162 CP Dora (1764_CR37) 2017; 534 V Patsula (1764_CR22) 2019; 9 B Gupta (1764_CR44) 2018; 80 S Lv (1764_CR14) 2013; 9 FS Carvalho (1764_CR5) 2014; 34 SH Voon (1764_CR13) 2017; 534 Y Qian (1764_CR38) 2018; 19 M Igartua (1764_CR34) 2002; 233 N Zafar (1764_CR17) 2014; 461 Z Xu (1764_CR30) 2010; 31 Z Fang (1764_CR26) 2019; 14 C Melguizo (1764_CR20) 2017; 18 M Muthiah (1764_CR23) 2013; 31 1764_CR15 A Demortiere (1764_CR40) 2011; 3 MJ Brady (1764_CR49) 1997; 15 YH Ling (1764_CR45) 1993; 53 J Shi (1764_CR11) 2017; 17 MA Mitry (1764_CR6) 2016; 10 |
| References_xml | – volume: 233 start-page: 149 issue: 1–2 year: 2002 end-page: 157 ident: CR34 article-title: Development and characterization of solid lipid nanoparticles loaded with magnetite publication-title: Int J Pharm contributor: fullname: Pedraz – volume: 73 start-page: 991 issue: 10 year: 2010 end-page: 995 ident: CR35 article-title: RRS measurements and DFT calculation for doxorubicin publication-title: Microsc Res Tech contributor: fullname: Cojoc – volume: 53 start-page: 1845 issue: 8 year: 1993 end-page: 1852 ident: CR45 article-title: Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells publication-title: Cancer Res contributor: fullname: Perez-Soler – volume: 112 start-page: 5818 issue: 11 year: 2012 end-page: 5878 ident: CR18 article-title: Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications publication-title: Chem Rev contributor: fullname: Couvreur – volume: 18 start-page: 3042 issue: 8 year: 2017 end-page: 3052 ident: CR20 article-title: Development and characterization of magnetite/poly(butylcyanoacrylate) nanoparticles for magnetic targeted delivery of cancer drugs publication-title: AAPS PharmSciTech contributor: fullname: Delgado – volume: 17 start-page: 20 issue: 1 year: 2017 end-page: 37 ident: CR11 article-title: Cancer nanomedicine: progress, challenges and opportunities publication-title: Nat Rev Cancer contributor: fullname: Farokhzad – volume: 39 start-page: 144 year: 2017 end-page: 152 ident: CR43 article-title: Ultrasound-assisted synthesis of pH-responsive nanovector based on PEG/chitosan coated magnetite nanoparticles for 5-FU delivery publication-title: Ultrason Sonochem contributor: fullname: Bafkary – volume: 31 start-page: 916 issue: 5 year: 2010 end-page: 922 ident: CR30 article-title: The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model publication-title: Biomaterials. contributor: fullname: Li – volume: 20 start-page: 188 issue: 5 year: 2019 ident: CR48 article-title: Dual-ligand modification of PEGylated liposomes used for targeted doxorubicin delivery to enhance anticancer efficacy publication-title: AAPS PharmSciTech contributor: fullname: Zheng – volume: 15 start-page: 974 issue: 3 year: 1997 end-page: 986 ident: CR49 article-title: Reliability and validity of the functional assessment of cancer therapy breast quality-of-life instrument publication-title: J Clin Onol contributor: fullname: Lloyd – ident: CR15 – volume: 117 start-page: 406 year: 2014 end-page: 413 ident: CR12 article-title: Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery publication-title: Colloids Surf B: Biointerfaces contributor: fullname: Hamidi – volume: 80 start-page: 173 year: 2016 end-page: 182 ident: CR21 article-title: Formation and characterization of beta-cyclodextrin (beta-CD) - polyethyleneglycol (PEG) - polyethyleneimine (PEI) coated Fe3O4 nanoparticles for loading and releasing 5-fluorouracil drug publication-title: Biomed Pharmacother contributor: fullname: Raj – volume: 7 start-page: 5861 issue: 38 year: 2019 end-page: 5872 ident: CR25 article-title: Hyaluronic acid modified doxorubicin loaded Fe3O4 nanoparticles effectively inhibit breast cancer metastasis publication-title: J Mater Chem B contributor: fullname: Zhang – volume: 14 start-page: 35 year: 2005 end-page: 48 ident: CR8 article-title: Mechanisms of drug resistance in cancer chemotherapy publication-title: Med Princ Pract contributor: fullname: Luqmani – volume: 31 start-page: 63 issue: 1 year: 2017 end-page: 75 ident: CR3 article-title: Anthracycline chemotherapy and cardiotoxicity publication-title: Cardiovasc Drugs Ther contributor: fullname: Yellon – volume: 34 start-page: 106 issue: 1 year: 2014 end-page: 135 ident: CR5 article-title: Doxorubicin- induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy publication-title: Med Res Rev contributor: fullname: Oliveira – volume: 12 start-page: 2033 year: 2017 end-page: 2044 ident: CR42 article-title: Lipid-coated iron oxide nanoparticles for dual- modal imaging of hepatocellular carcinoma publication-title: Int J Nanomedicine contributor: fullname: Gan – volume: 3 start-page: 225 issue: 1 year: 2011 end-page: 232 ident: CR40 article-title: Size-dependent properties of magnetic iron oxide nanocrystals publication-title: Nanoscale. contributor: fullname: Guillon – volume: 10 start-page: 257 year: 2015 end-page: 270 ident: CR41 article-title: Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer publication-title: Int J Nanomedicine contributor: fullname: Liu – volume: 114 start-page: 7210 issue: 28 year: 2017 end-page: 7215 ident: CR28 article-title: Optimal multivalent targeting of membranes with many distinct receptors publication-title: Proc Natl Acad Sci U S A contributor: fullname: Frenkel – volume: 200 start-page: 138 year: 2015 end-page: 157 ident: CR10 article-title: Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications publication-title: J Control Release contributor: fullname: Huwyler – volume: 19 start-page: 3599 issue: 8 year: 2018 end-page: 3608 ident: CR38 article-title: Preparation and evaluation of probucol-phospholipid complex with enhanced bioavailability and no food effect publication-title: AAPS PharmSciTech contributor: fullname: Ren – volume: 31 start-page: 1224 issue: 8 year: 2013 end-page: 1236 ident: CR23 article-title: Surface modification of iron oxide nanoparticles by biocompatible polymers for tissue imaging and targeting publication-title: Biotechnol Adv contributor: fullname: Cho – volume: 98 start-page: 19 year: 2016 end-page: 34 ident: CR1 article-title: Recent advances of cocktail chemotherapy by combination drug delivery systems publication-title: Adv Drug Deliv Rev contributor: fullname: Gu – volume: 162 start-page: 45 issue: 1 year: 2012 end-page: 55 ident: CR16 article-title: Nanotechnology applied to overcome tumor drug resistance publication-title: J Control Release contributor: fullname: Sun – volume: 80 start-page: 364 year: 2018 end-page: 377 ident: CR44 article-title: Hyaluronic acid- capped compact silica-supported mescoporous titania nanoparticles for ligand-directed delivery of doxorubicin publication-title: Acta Biomater contributor: fullname: Gautam – volume: 80 start-page: 364 year: 2018 end-page: 377 ident: CR27 article-title: Hyaluronic acid- capped compact silica-supported mesoporous titania nanoparticles for ligand-directed delivery of doxorubicin publication-title: Acta Biomater contributor: fullname: Gautam – volume: 13 start-page: 1899 year: 2018 end-page: 1915 ident: CR39 article-title: Dextran-coated superparamagetic iron oxide nanoparticles for magnetic resonance imaging: evaluation of size-dependent imaging properties, storage stability and safety publication-title: Int J Pharm contributor: fullname: Jordan – volume: 3 start-page: 891 issue: 12 year: 2004 end-page: 895 ident: CR32 article-title: Ultra-large-scale syntheses of monodisperse nanocrystals publication-title: Nat Mater contributor: fullname: Kim – volume: 461 start-page: 351 issue: 1–2 year: 2014 end-page: 366 ident: CR17 article-title: Cyclodextrin containing biodegradable particles: from preparation to drug delivery applications publication-title: Int J Pharm contributor: fullname: Elaissari – volume: 8 start-page: 4631 year: 2013 end-page: 4639 ident: CR36 article-title: Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery publication-title: Int J Nanomedicine contributor: fullname: Guo – volume: 30 start-page: 129 year: 2018 end-page: 137 ident: CR33 article-title: Plectin-1targeted dual-modality nanoparticles for pancreatic cancer imaging publication-title: EbioMedicine. contributor: fullname: Liu – volume: 83 start-page: 219 year: 2016 end-page: 232 ident: CR46 article-title: Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy publication-title: Biomaterials contributor: fullname: Sheng – volume: 196 start-page: 370 year: 2014 end-page: 383 ident: CR47 article-title: ROS-triggered and regenerating anticancer nanosystem: an effective strategy to subdue tumor’s multidrug resistance publication-title: J Control Release contributor: fullname: Asghar – volume: 43 start-page: 723 issue: 8 year: 2016 end-page: 737 ident: CR4 article-title: Molecular mechanisms for tumour resistance to chemotherapy publication-title: Clin Exp Pharmacol Physiol contributor: fullname: Zhou – volume: 1 start-page: 10 issue: 1 year: 2016 end-page: 29 ident: CR9 article-title: Nanoparticles in the clinic publication-title: Bioeng Transl Med contributor: fullname: Mitragotri – volume: 115 start-page: 10637 issue: 19 year: 2015 end-page: 10689 ident: CR19 article-title: Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy publication-title: Chem Rev contributor: fullname: Cheon – volume: 84 start-page: 181 issue: 2 year: 2012 end-page: 199 ident: CR2 article-title: Cancer chemotherapy: a critical analysis of its 60 years of history publication-title: Crit Rev Oncol Hematol contributor: fullname: Galmarini – volume: 7 start-page: 511 year: 2012 end-page: 526 ident: CR24 article-title: Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers publication-title: Int J Nanomedicine contributor: fullname: Davaran – ident: CR31 – volume: 103 start-page: 405 issue: 2 year: 2005 end-page: 418 ident: CR29 article-title: Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor publication-title: J Control Release contributor: fullname: Bae – volume: 10 start-page: 17 year: 2016 end-page: 24 ident: CR6 article-title: Doxorubicin induced heart failure: phenotype and molecular mechanisms publication-title: Int J Cardiol Heart Vasc contributor: fullname: Edwards – volume: 9 start-page: 9330 year: 2013 end-page: 9342 ident: CR14 article-title: Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy publication-title: Acta Biomater contributor: fullname: Tang – volume: 534 start-page: 1 issue: 1–2 year: 2017 end-page: 13 ident: CR37 article-title: Improved oral bioavailability and therapeutic efficacy of erlotinib through molecular complexation with phospholipid publication-title: Int J Pharm contributor: fullname: Suresh – volume: 14 start-page: 5785 year: 2019 end-page: 5797 ident: CR26 article-title: Hyaluronic acid-modified mesoporous silica-coated superparamagnetic Fe3O4 nanoparticles for targeted drug delivery publication-title: Int J Nanomedicine contributor: fullname: Gao – volume: 9 start-page: 10765 issue: 1 year: 2019 ident: CR22 article-title: Synthesis and modification of uniform PEG-neridronate-modified magnetic nanoparticles determines prolonged blood circulation and biodistribution in a mouse preclinical model publication-title: Sci Rep contributor: fullname: Francova – volume: 21 start-page: 440 issue: 7 year: 2011 end-page: 446 ident: CR7 article-title: Doxorubicin pathways: pharmacodynamics and adverse effects publication-title: Altman Pharmacogenet Genomics contributor: fullname: Marsh – volume: 534 start-page: 136 issue: 1–2 year: 2017 end-page: 143 ident: CR13 article-title: Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: in vitro and in vivo studies publication-title: Int J Pharm contributor: fullname: Kiew – volume: 39 start-page: 144 year: 2017 ident: 1764_CR43 publication-title: Ultrason Sonochem doi: 10.1016/j.ultsonch.2017.04.025 contributor: fullname: S Khoee – volume: 34 start-page: 106 issue: 1 year: 2014 ident: 1764_CR5 publication-title: Med Res Rev doi: 10.1002/med.21280 contributor: fullname: FS Carvalho – volume: 83 start-page: 219 year: 2016 ident: 1764_CR46 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2016.01.023 contributor: fullname: Y Zhang – volume: 10 start-page: 257 year: 2015 ident: 1764_CR41 publication-title: Int J Nanomedicine contributor: fullname: X Zhao – volume: 19 start-page: 3599 issue: 8 year: 2018 ident: 1764_CR38 publication-title: AAPS PharmSciTech doi: 10.1208/s12249-018-1157-2 contributor: fullname: Y Qian – volume: 112 start-page: 5818 issue: 11 year: 2012 ident: 1764_CR18 publication-title: Chem Rev doi: 10.1021/cr300068p contributor: fullname: LH Reddy – volume: 3 start-page: 225 issue: 1 year: 2011 ident: 1764_CR40 publication-title: Nanoscale. doi: 10.1039/C0NR00521E contributor: fullname: A Demortiere – volume: 10 start-page: 17 year: 2016 ident: 1764_CR6 publication-title: Int J Cardiol Heart Vasc contributor: fullname: MA Mitry – ident: 1764_CR15 doi: 10.3390/pharmaceutics11020063 – volume: 18 start-page: 3042 issue: 8 year: 2017 ident: 1764_CR20 publication-title: AAPS PharmSciTech doi: 10.1208/s12249-017-0792-3 contributor: fullname: C Melguizo – ident: 1764_CR31 doi: 10.1002/adma.201902604 – volume: 162 start-page: 45 issue: 1 year: 2012 ident: 1764_CR16 publication-title: J Control Release doi: 10.1016/j.jconrel.2012.05.051 contributor: fullname: Z Gao – volume: 7 start-page: 511 year: 2012 ident: 1764_CR24 publication-title: Int J Nanomedicine contributor: fullname: A Akbarzadeh – volume: 114 start-page: 7210 issue: 28 year: 2017 ident: 1764_CR28 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1704226114 contributor: fullname: T Curk – volume: 31 start-page: 63 issue: 1 year: 2017 ident: 1764_CR3 publication-title: Cardiovasc Drugs Ther doi: 10.1007/s10557-016-6711-0 contributor: fullname: JV McGowan – volume: 7 start-page: 5861 issue: 38 year: 2019 ident: 1764_CR25 publication-title: J Mater Chem B doi: 10.1039/C9TB01250H contributor: fullname: T Gong – volume: 20 start-page: 188 issue: 5 year: 2019 ident: 1764_CR48 publication-title: AAPS PharmSciTech doi: 10.1208/s12249-019-1385-0 contributor: fullname: C Li – volume: 13 start-page: 1899 year: 2018 ident: 1764_CR39 publication-title: Int J Pharm contributor: fullname: H Unterweger – volume: 80 start-page: 173 year: 2016 ident: 1764_CR21 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.03.015 contributor: fullname: G Prabha – volume: 80 start-page: 364 year: 2018 ident: 1764_CR44 publication-title: Acta Biomater doi: 10.1016/j.actbio.2018.09.006 contributor: fullname: B Gupta – volume: 21 start-page: 440 issue: 7 year: 2011 ident: 1764_CR7 publication-title: Altman Pharmacogenet Genomics doi: 10.1097/FPC.0b013e32833ffb56 contributor: fullname: CF Thorn – volume: 534 start-page: 136 issue: 1–2 year: 2017 ident: 1764_CR13 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2017.10.023 contributor: fullname: SH Voon – volume: 30 start-page: 129 year: 2018 ident: 1764_CR33 publication-title: EbioMedicine. doi: 10.1016/j.ebiom.2018.03.008 contributor: fullname: X Chen – volume: 14 start-page: 35 year: 2005 ident: 1764_CR8 publication-title: Med Princ Pract doi: 10.1159/000086183 contributor: fullname: YA Luqmani – volume: 115 start-page: 10637 issue: 19 year: 2015 ident: 1764_CR19 publication-title: Chem Rev doi: 10.1021/acs.chemrev.5b00112 contributor: fullname: N Lee – volume: 103 start-page: 405 issue: 2 year: 2005 ident: 1764_CR29 publication-title: J Control Release doi: 10.1016/j.jconrel.2004.12.018 contributor: fullname: ES Lee – volume: 17 start-page: 20 issue: 1 year: 2017 ident: 1764_CR11 publication-title: Nat Rev Cancer doi: 10.1038/nrc.2016.108 contributor: fullname: J Shi – volume: 53 start-page: 1845 issue: 8 year: 1993 ident: 1764_CR45 publication-title: Cancer Res contributor: fullname: YH Ling – volume: 9 start-page: 9330 year: 2013 ident: 1764_CR14 publication-title: Acta Biomater doi: 10.1016/j.actbio.2013.08.015 contributor: fullname: S Lv – volume: 9 start-page: 10765 issue: 1 year: 2019 ident: 1764_CR22 publication-title: Sci Rep doi: 10.1038/s41598-019-47262-w contributor: fullname: V Patsula – volume: 196 start-page: 370 year: 2014 ident: 1764_CR47 publication-title: J Control Release doi: 10.1016/j.jconrel.2014.09.020 contributor: fullname: Z Su – volume: 534 start-page: 1 issue: 1–2 year: 2017 ident: 1764_CR37 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2017.09.071 contributor: fullname: CP Dora – volume: 15 start-page: 974 issue: 3 year: 1997 ident: 1764_CR49 publication-title: J Clin Onol doi: 10.1200/JCO.1997.15.3.974 contributor: fullname: MJ Brady – volume: 1 start-page: 10 issue: 1 year: 2016 ident: 1764_CR9 publication-title: Bioeng Transl Med doi: 10.1002/btm2.10003 contributor: fullname: AC Anselmo – volume: 31 start-page: 1224 issue: 8 year: 2013 ident: 1764_CR23 publication-title: Biotechnol Adv doi: 10.1016/j.biotechadv.2013.03.005 contributor: fullname: M Muthiah – volume: 98 start-page: 19 year: 2016 ident: 1764_CR1 publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2015.10.022 contributor: fullname: Q Hu – volume: 84 start-page: 181 issue: 2 year: 2012 ident: 1764_CR2 publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2012.03.002 contributor: fullname: D Galmarini – volume: 461 start-page: 351 issue: 1–2 year: 2014 ident: 1764_CR17 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2013.12.004 contributor: fullname: N Zafar – volume: 8 start-page: 4631 year: 2013 ident: 1764_CR36 publication-title: Int J Nanomedicine contributor: fullname: W Ding – volume: 117 start-page: 406 year: 2014 ident: 1764_CR12 publication-title: Colloids Surf B: Biointerfaces doi: 10.1016/j.colsurfb.2014.03.001 contributor: fullname: S Sadighian – volume: 12 start-page: 2033 year: 2017 ident: 1764_CR42 publication-title: Int J Nanomedicine doi: 10.2147/IJN.S128525 contributor: fullname: J Liang – volume: 14 start-page: 5785 year: 2019 ident: 1764_CR26 publication-title: Int J Nanomedicine doi: 10.2147/IJN.S213974 contributor: fullname: Z Fang – volume: 31 start-page: 916 issue: 5 year: 2010 ident: 1764_CR30 publication-title: Biomaterials. doi: 10.1016/j.biomaterials.2009.09.103 contributor: fullname: Z Xu – volume: 43 start-page: 723 issue: 8 year: 2016 ident: 1764_CR4 publication-title: Clin Exp Pharmacol Physiol doi: 10.1111/1440-1681.12581 contributor: fullname: ST Pan – volume: 233 start-page: 149 issue: 1–2 year: 2002 ident: 1764_CR34 publication-title: Int J Pharm doi: 10.1016/S0378-5173(01)00936-X contributor: fullname: M Igartua – volume: 3 start-page: 891 issue: 12 year: 2004 ident: 1764_CR32 publication-title: Nat Mater doi: 10.1038/nmat1251 contributor: fullname: J Park – volume: 200 start-page: 138 year: 2015 ident: 1764_CR10 publication-title: J Control Release doi: 10.1016/j.jconrel.2014.12.030 contributor: fullname: A Wicki – volume: 80 start-page: 364 year: 2018 ident: 1764_CR27 publication-title: Acta Biomater doi: 10.1016/j.actbio.2018.09.006 contributor: fullname: B Gupta – volume: 73 start-page: 991 issue: 10 year: 2010 ident: 1764_CR35 publication-title: Microsc Res Tech doi: 10.1002/jemt.20849 contributor: fullname: G Das |
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| Title | Lipid/Hyaluronic Acid–Coated Doxorubicin-Fe3O4 as a Dual-Targeting Nanoparticle for Enhanced Cancer Therapy |
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