Rest the brain to learn new gait patterns after stroke

• Published in: Journal of neuroengineering and rehabilitation Vol. 21; no. 1; pp. 192 - 14
• Main Authors: Krishnan, Chandramouli, Augenstein, Thomas E, Claflin, Edward S, Hemsley, Courtney R, Washabaugh, Edward P, Ranganathan, Rajiv
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29-10-2024; BioMed Central; BMC
• Subjects: Adult; Aged; Brain - physiopathology; Care and treatment; Case-Control Studies; Complications and side effects; Consolidation; Error-based learning; Female; Gait - physiology; Gait disorders; Hemiparesis; Humans; Learning - physiology; Male; Middle Aged; Motor learning; Motor Skills - physiology; Motor task; Neurological research; Prospective Studies; Psychomotor disorders; Recovery of function; Rest - physiology; Risk factors; Skill acquisition; Stroke (Disease); Stroke - complications; Stroke - physiopathology; Stroke Rehabilitation - methods; Walking - physiology; United States; Hemiparesis; Motor task; Error-based learning; Skill acquisition; Consolidation
• ISSN: 1743-0003; 1743-0003
• DOI: 10.1186/s12984-024-01494-8

The ability to relearn a lost skill is critical to motor recovery after a stroke. Previous studies indicate that stroke typically affects the processes underlying motor control and execution but not the learning of those skills. However, these studies could be confounded by the presence of significant motor impairments. Furthermore, prior research involving the upper extremity indicates that stroke survivors have an advantage in offline motor learning when compared with controls. However, this has not been examined using motor acuity tasks (i.e., tasks focusing on the quality of executed actions) that have direct functional relevance to rehabilitation.
Investigate how stroke affects leg motor skill learning during walking in stroke survivors.
Twenty-five participants (10 stroke; 15 controls) were recruited for this prospective, case-control study. Participants learned a novel foot-trajectory tracking task on two consecutive days while walking on a treadmill. The task necessitated greater hip and knee flexion during the swing phase of the gait. Online learning was measured by comparing tracking error at the beginning and end of each practice session, offline (rest-driven) learning was measured by comparing the end of the first practice session to the beginning of the second, and retention was measured by comparing the beginning of the first practice session to the beginning of the second. Online learning, offline learning, and retention were compared between the stroke survivors and uninjured controls.
Stroke survivors improved their tracking performance on the first day (p = 0.033); however, the amount of learning in stroke survivors was lower in comparison with the control group on both days (p ≤ 0.05). Interestingly, stroke survivors showed higher offline learning gains when compared with uninjured controls (p = 0.011).
Even stroke survivors with no perceivable motor impairments have difficulty acquiring new motor skills related to walking, which may be related to the underlying neural damage caused at the time of stroke. Furthermore, stroke survivors may require longer training with adequate rest to acquire new motor skills.