Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus

• Published in: Biotechnology letters Vol. 23; no. 7; pp. 513 - 517
• Main Authors: KIM, Dong-Hyun, YANG, Byung-Keun, JEONG, Sang-Chul, PARK, Jun-Bo, CHO, Sung-Pill, SURAJIT DAS, YUN, Jong-Won, SONG, Chi-Hyun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01-04-2001; Springer Nature B.V
• Subjects: alanine transaminase; aspartate aminotransferase; Bacteriology; Biological and medical sciences; Biotechnology; cholesterol; Diabetes; Fundamental and applied biological sciences. Psychology; glucose; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Other active biomolecules; Phellinus linteus; polysaccharides; Production of active biomolecules; triacylglycerol; Fungi; Hypoglycemic agent; Treatment; Submerged culture; Diabetes mellitus; Production; Microorganism culture; Basidiomycetes; Extracellular; Polysaccharide; Biological activity; Thallophyta
• ISSN: 0141-5492; 1573-6776
• DOI: 10.1023/A:1010312513878

Mycelial growth and extracellular polysaccharide production of Phellinus linteus were optimal at pH 5 and 25 °C. Maximum biomass production (14.2 g l^sup -1^) was after 15 d of cultivation, whereas, extracellular polysaccharide was maximal (3.5 g l^sup -1^) after 21 d. The hypoglycemic effect of the polysaccharide, investigated in streptozotocin-induced diabetic rats, decreased plasma glucose, total cholesterol and triacylglycerol concentrations by 49%, 32%, and 28%, respectively, and aspartate aminotransferase activity by 20%. The results indicate the potential of this polysaccharide to prevent hyperglycemia in diabetic patients.[PUBLICATION ABSTRACT]