Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

A number of recent studies have highlighted the importance of autophagy and the ubiquitin-proteasome in the pathogenesis of muscle wasting in different types of inherited muscle disorders. Autophagy is crucial for the removal of dysfunctional organelles and protein aggregates, whereas the ubiquitin-...

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Bibliographic Details
Published in:	Journal of cell science Vol. 126; no. Pt 23; pp. 5325 - 5333
Main Authors:	Sandri, Marco, Coletto, Luisa, Grumati, Paolo, Bonaldo, Paolo
Format:	Journal Article
Language:	English
Published:	England 01-12-2013
Subjects:	Autophagy - genetics Gene Expression Regulation Humans Lysosomes - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - genetics Muscular Atrophy - metabolism Muscular Atrophy - pathology Muscular Dystrophies - genetics Muscular Dystrophies - metabolism Muscular Dystrophies - pathology Proteasome Endopeptidase Complex - metabolism Proteolysis Signal Transduction Ubiquitination Ubiquitins - genetics Ubiquitins - metabolism Dystrophy Muscle wasting Autophagy Skeletal muscle Duchenne Myopathy
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