Molecular Architecture of Myelinated Nerve Fibers Leaky Paranodal Junctions and Paranodal Dysmyelination

Myelinated nerve fibers have evolved to optimize signal propagation. Each myelin segment is attached to the axon by the unique paranodal axoglial junction (PNJ), a highly complex structure that serves to define axonal ion channel domains and to direct nodal action currents through adjacent nodes. Su...

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Bibliographic Details

Published in:	The Neuroscientist (Baltimore, Md.) Vol. 19; no. 6; pp. 629 - 641
Main Authors:	Rosenbluth, Jack, Mierzwa, Amanda, Shroff, Seema
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-12-2013
Subjects:	Animals Axons - ultrastructure Humans Mice Nerve Fibers, Myelinated - pathology Nerve Fibers, Myelinated - physiology Nerve Fibers, Myelinated - ultrastructure Neuroglia - ultrastructure Ranvier's Nodes - ultrastructure myelin nerve fibers demyelination multiple sclerosis
Online Access:	Get full text
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