765G＞C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 34; pp. 5473 - 5478
• Main Authors: Pereira, Carina, Sousa, Hugo, Ferreira, Paula, Fragoso, Maria, Moreira-Dias, Luís, Lopes, Carlos, Medeiros, Rui, Dinis-Ribeiro, Mário
• Format: Journal Article
• Language: English
• Published: United States and ICBAS, Abel Salazar Institute for the Biomedical Sciences, Porto,Portugal%Oncology Department, Portuguese Institute of Oncology of Porto, Portugal%Gastroenterology Department, Portuguese Institute of Oncology of Porto, Portugal%Gastroenterology Department, Portuguese Institute of Oncology of Porto, Portugal 14-09-2006; Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Portugal%Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Portugal; and Cintesis / Faculty of Medicine University of Porto, Porto, Portugal; Baishideng Publishing Group Co., Limited
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adult; Aged; Alleles; Atrophy - genetics; Atrophy - pathology; Cross-Sectional Studies; Cyclooxygenase 2 - genetics; Cystine - analysis; DNA, Neoplasm - analysis; Female; Gastric Cancer; Genetic Predisposition to Disease; Guanine - analysis; Humans; Intestines - pathology; Male; Membrane Proteins - genetics; Metaplasia - genetics; Metaplasia - pathology; Middle Aged; Polymorphism, Genetic - genetics; Portugal; Regression Analysis; Risk Factors; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; 基因多态性; 易感性; 肠生化; Portugal; Atrophy; COX-2; Intestinal metaplasia; Pharmacogenomic; Gastric adenocarcinoma; PCR-RFLP; Polymorphism
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i34.5473

AIM： To investigate the relationship between the -765G 〉 C COX-2 polymorphism and the development of different gastric lesions： atrophy or intestinal metaplasia and gastric adenocarcinoma.
METHODS： A cross-sectional study was performed involving 320 Portuguese individuals （210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia） using a PCR-RFLP method.
RESULTS： -765C allele was overrepresented in the patients with gastric adenocarcinoma （51%） when compared either with the control group （38%） or patients with atrophy or intestinal metaplasia （27%）. Callele was found to be very common in our population （0.22）, and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele （OR = 2.67, 95% CI = 1.03-6.93; P = 0.04）.
CONCLUSION： -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.