Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis
Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples. We measured IL-8 expression by using reverse transcriptase-polymerase ch...
Saved in:
| Published in: | Annals of surgical oncology Vol. 12; no. 10; pp. 800 - 807 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Springer Nature B.V
01-10-2005
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples.
We measured IL-8 expression by using reverse transcriptase-polymerase chain reaction in clinical HCC tissues from 45 patients who underwent surgical resection. We then assessed correlations between IL-8 expression and microvessel growth or clinicopathologic factors. We also elucidated the in vitro effect of IL-8 on HepG2 development by using fluorometric assays of proliferation, chemotaxis, and invasion.
The expression of IL-8 did not significantly correlate with the microvessel count in HCC tissues, but the incidence of microscopic vessel invasion was significantly higher in IL-8-positive than in IL-8-negative tissues. Thus, more IL-8 was expressed in HCCs at pathologic stage III/IV than in those at stage I/II. Assays in vitro showed that IL-8 stimulates HepG2 chemotactic and invasive activities rather than cell proliferation.
The expression of IL-8 in human HCC has more relevance to metastatic potential, such as vessel invasion, than to angiogenesis or cell proliferation. |
|---|---|
| AbstractList | Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples.
We measured IL-8 expression by using reverse transcriptase-polymerase chain reaction in clinical HCC tissues from 45 patients who underwent surgical resection. We then assessed correlations between IL-8 expression and microvessel growth or clinicopathologic factors. We also elucidated the in vitro effect of IL-8 on HepG2 development by using fluorometric assays of proliferation, chemotaxis, and invasion.
The expression of IL-8 did not significantly correlate with the microvessel count in HCC tissues, but the incidence of microscopic vessel invasion was significantly higher in IL-8-positive than in IL-8-negative tissues. Thus, more IL-8 was expressed in HCCs at pathologic stage III/IV than in those at stage I/II. Assays in vitro showed that IL-8 stimulates HepG2 chemotactic and invasive activities rather than cell proliferation.
The expression of IL-8 in human HCC has more relevance to metastatic potential, such as vessel invasion, than to angiogenesis or cell proliferation. BACKGROUNDAngiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples.METHODSWe measured IL-8 expression by using reverse transcriptase-polymerase chain reaction in clinical HCC tissues from 45 patients who underwent surgical resection. We then assessed correlations between IL-8 expression and microvessel growth or clinicopathologic factors. We also elucidated the in vitro effect of IL-8 on HepG2 development by using fluorometric assays of proliferation, chemotaxis, and invasion.RESULTSThe expression of IL-8 did not significantly correlate with the microvessel count in HCC tissues, but the incidence of microscopic vessel invasion was significantly higher in IL-8-positive than in IL-8-negative tissues. Thus, more IL-8 was expressed in HCCs at pathologic stage III/IV than in those at stage I/II. Assays in vitro showed that IL-8 stimulates HepG2 chemotactic and invasive activities rather than cell proliferation.CONCLUSIONSThe expression of IL-8 in human HCC has more relevance to metastatic potential, such as vessel invasion, than to angiogenesis or cell proliferation. Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the expression of interleukin (IL)-8, a potent angiogenic factor, in HCC samples. We measured IL-8 expression by using reverse transcriptase-polymerase chain reaction in clinical HCC tissues from 45 patients who underwent surgical resection. We then assessed correlations between IL-8 expression and microvessel growth or clinicopathologic factors. We also elucidated the in vitro effect of IL-8 on HepG2 development by using fluorometric assays of proliferation, chemotaxis, and invasion. The expression of IL-8 did not significantly correlate with the microvessel count in HCC tissues, but the incidence of microscopic vessel invasion was significantly higher in IL-8-positive than in IL-8-negative tissues. Thus, more IL-8 was expressed in HCCs at pathologic stage III/IV than in those at stage I/II. Assays in vitro showed that IL-8 stimulates HepG2 chemotactic and invasive activities rather than cell proliferation. The expression of IL-8 in human HCC has more relevance to metastatic potential, such as vessel invasion, than to angiogenesis or cell proliferation. |
| Author | Kubo, Fumitake Aikou, Takashi Kawaida, Koichi Nuruki, Kensuke Hiwatashi, Kiyokazu Sakoda, Masahiko Ueno, Shinichi |
| Author_xml | – sequence: 1 givenname: Fumitake surname: Kubo fullname: Kubo, Fumitake email: f-kubo@m3.kufm.kagoshima-u.ac.jp organization: Course of Advanced Therapeutics, Field of Oncology, Department of Surgical Oncology and Digestive Surgery, KagoshimaUniversity Graduate School of Medicine and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. f-kubo@m3.kufm.kagoshima-u.ac.jp – sequence: 2 givenname: Shinichi surname: Ueno fullname: Ueno, Shinichi – sequence: 3 givenname: Kiyokazu surname: Hiwatashi fullname: Hiwatashi, Kiyokazu – sequence: 4 givenname: Masahiko surname: Sakoda fullname: Sakoda, Masahiko – sequence: 5 givenname: Koichi surname: Kawaida fullname: Kawaida, Koichi – sequence: 6 givenname: Kensuke surname: Nuruki fullname: Nuruki, Kensuke – sequence: 7 givenname: Takashi surname: Aikou fullname: Aikou, Takashi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16132378$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkUtrHDEMgE1JaR7tubdgcshtNn7MeLzHENI2EMih7dlobE0yyYy98WNDT_3r8bILhV4kgT4Jie-UHPngkZCvnK24aLur658PK8FYt2L9ivHuAznhnWybVml-VGumdLMWqjsmpyk9M8Z7ybpP5JgrLoXs9Qn5e-czxhnLy-SppjU8lQVqxA3kYHGeywyRWoh28mEBakOMOEPGRN-m_FQ73mIFKlmnt5Cm4GkY6RZTwjnRoWTqQ97DuSwhUvCPU3hEj2lKn8nHEeaEXw75jPz-dvvr5kdz__D97ub6vrFSiNyAVQMiV3ZwfOS7P6zQfC3XTkoBVvfKcQBnFVgupRudw7Ef-eBAjho6Kc_I5X7vJobXgimbZUq7o8FjKMkorUQrWFvBi__A51Cir7cZIXrZr3UrKnS1h2wMKUUczSZOC8Q_hjOzE2OqGLMTY1hvqpg6cX5YW4YF3T_-YEK-A7F7je0 |
| CitedBy_id | crossref_primary_10_1111_jcmm_12408 crossref_primary_10_1111_j_1582_4934_2011_01337_x crossref_primary_10_1158_0008_5472_CAN_10_3100 crossref_primary_10_1002_ar_20668 crossref_primary_10_1038_srep24558 crossref_primary_10_3892_ol_2014_2531 crossref_primary_10_4240_wjgs_v4_i3_62 crossref_primary_10_1093_carcin_bgaa106 crossref_primary_10_1016_j_cyto_2017_02_020 crossref_primary_10_1016_j_jss_2008_09_015 crossref_primary_10_1007_s00432_013_1554_6 crossref_primary_10_1038_nrclinonc_2011_30 crossref_primary_10_1155_2009_461492 crossref_primary_10_1111_j_1349_7006_2009_01087_x crossref_primary_10_1134_S2079086415060080 crossref_primary_10_1245_s10434_013_2914_9 crossref_primary_10_1111_j_1872_034X_2009_00619_x crossref_primary_10_1186_1756_9966_32_51 crossref_primary_10_3390_molecules18032549 crossref_primary_10_1016_j_critrevonc_2011_05_005 crossref_primary_10_1186_1479_5876_10_41 crossref_primary_10_1084_jem_20072509 crossref_primary_10_1016_j_biomaterials_2015_03_035 crossref_primary_10_5402_2012_587259 crossref_primary_10_1021_jf103904b crossref_primary_10_3390_ijms241512512 crossref_primary_10_1038_s41418_019_0413_7 crossref_primary_10_1089_dna_2011_1438 crossref_primary_10_1007_s12032_010_9780_0 crossref_primary_10_3109_07357907_2012_732161 crossref_primary_10_1016_j_abb_2020_108571 crossref_primary_10_1016_j_coph_2009_06_020 crossref_primary_10_1016_j_canlet_2006_01_008 crossref_primary_10_1053_j_gastro_2015_08_032 crossref_primary_10_1186_1476_5926_9_1 crossref_primary_10_1177_03946320241249445 crossref_primary_10_1073_pnas_1419119111 crossref_primary_10_1111_jgh_12091 crossref_primary_10_1371_journal_pone_0139977 crossref_primary_10_3390_molecules16086365 crossref_primary_10_1186_1479_5876_5_3 crossref_primary_10_1038_gene_2008_86 crossref_primary_10_1155_2021_3249816 crossref_primary_10_1111_jcmm_12153 crossref_primary_10_3892_or_2016_5336 crossref_primary_10_1186_s13046_016_0313_3 crossref_primary_10_1007_s10495_015_1185_2 crossref_primary_10_1016_j_ajpath_2010_11_059 crossref_primary_10_1007_s11060_010_0261_2 |
| Cites_doi | 10.1159/000028045 10.1016/S1386-6346(02)00144-4 10.1016/0092-8674(94)90187-2 10.1038/scientificamerican0292-54 10.1002/hep.510230309 10.4049/jimmunol.143.4.1366 10.1038/labinvest.3780401 10.1056/NEJM199101033240101 10.1006/bbrc.2000.3925 10.1084/jem.167.6.1883 10.1093/annonc/mdf078 10.1016/1043-4666(89)91043-0 10.1016/S0021-9258(17)45336-1 10.1093/jnci/82.1.4 10.1016/0046-8177(92)90344-3 10.1002/hep.510270613 10.1148/radiology.171.2.2539607 10.1016/S0021-9258(19)49853-0 10.1126/science.1281554 10.1007/BF02591427 10.1002/hep.1840060432 10.1002/1097-0142(20011115)92:10<2628::AID-CNCR1616>3.0.CO;2-F |
| ContentType | Journal Article |
| Copyright | The Society of Surgical Oncology, Inc. 2005 |
| Copyright_xml | – notice: The Society of Surgical Oncology, Inc. 2005 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TO 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PQEST PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.1245/ASO.2005.07.015 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts ProQuest - Health & Medical Complete保健、医学与药学数据库 ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central AUTh Library subscriptions: ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Oncogenes and Growth Factors Abstracts ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Pharma Collection ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) AIDS and Cancer Research Abstracts ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Oncogenes and Growth Factors Abstracts |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1534-4681 |
| EndPage | 807 |
| ExternalDocumentID | 927641341 10_1245_ASO_2005_07_015 16132378 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .VR 06C 06D 0R~ 0VY 199 1N0 1SB 203 23M 28- 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2WC 2~H 30V 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5VS 67Z 6J9 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAEOY AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABUWZ ABWNU ABXPI ACAOD ACBXY ACDTI ACGFO ACGFS ACHSB ACHVE ACHXU ACIHN ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACREN ACUDM ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYOE ADZKW AEAQA AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFJLC AFKRA AFLOW AFQWF AFWTZ AFYQB AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJOOF AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMTXH AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BAWUL BBWZM BDATZ BENPR BGNMA BPHCQ BVXVI C1A CAG CCPQU CGR COF CS3 CSCUP CUY CVF DDRTE DIK DL5 DNIVK DPUIP E3Z EBD EBLON EBS ECM EIF EIOEI EJD EMOBN EN4 ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GX1 GXS H13 HEOXT HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IH2 IHE IJ- IKXTQ IMOTQ IWAJR IXC IXD IXE IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LLZTM M1P M4Y MA- N2Q N9A NB0 NDZJH NPM NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD OWW P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 WOQ YFH YLTOR Z45 Z7U Z7X Z82 Z83 Z87 Z8O Z8V Z91 ZMTXR ZOVNA AAYXX CITATION 7TO 7XB 8FK H94 K9. PQEST PQUKI PRINS 7X8 |
| ID | FETCH-LOGICAL-c322t-ac6bee16cbd1f10173c281939d332ac876d1aadc6ac133dfddef7f1bda3f8a533 |
| ISSN | 1068-9265 |
| IngestDate | Fri Oct 25 01:26:02 EDT 2024 Thu Oct 10 18:50:10 EDT 2024 Fri Nov 22 00:56:53 EST 2024 Tue Oct 15 23:32:50 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c322t-ac6bee16cbd1f10173c281939d332ac876d1aadc6ac133dfddef7f1bda3f8a533 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 16132378 |
| PQID | 227379842 |
| PQPubID | 32486 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_68624204 proquest_journals_227379842 crossref_primary_10_1245_ASO_2005_07_015 pubmed_primary_16132378 |
| PublicationCentury | 2000 |
| PublicationDate | 2005-Oct 2005-10-00 20051001 |
| PublicationDateYYYYMMDD | 2005-10-01 |
| PublicationDate_xml | – month: 10 year: 2005 text: 2005-Oct |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: New York |
| PublicationTitle | Annals of surgical oncology |
| PublicationTitleAlternate | Ann Surg Oncol |
| PublicationYear | 2005 |
| Publisher | Springer Nature B.V |
| Publisher_xml | – name: Springer Nature B.V |
| References | RM Strieter (6662_CR9) 1992; 141 N Weidner (6662_CR7) 1991; 324 N Mukaida (6662_CR11) 1989; 143 S Bosari (6662_CR18) 1992; 23 K Matsushima (6662_CR14) 1998; 167 IJ Fidler (6662_CR4) 1994; 79 J Akiba (6662_CR27) 2001; 18 M Luca (6662_CR26) 1997; 151 M Masahiro (6662_CR21) 1996; 23 S Ueno (6662_CR3) 2002; 24 J Folkman (6662_CR5) 1990; 82 K Okuda (6662_CR1) 1986; 6 LA Liotta (6662_CR25) 1992; 226 D Masuya (6662_CR17) 2001; 92 K Inoue (6662_CR24) 2000; 6 Liver Cancer Study Group of Japan (6662_CR20) 2000 ON El-Assal (6662_CR22) 1998; 27 M Bar-Eli (6662_CR10) 1999; 67 J Folkman (6662_CR6) 1992; 267 K Sakamoto (6662_CR15) 1992; 22 N Mukaida (6662_CR12) 1990; 265 A Iguchi (6662_CR16) 2000; 279 K Matsushima (6662_CR13) 1989; 1 J Fujimoto (6662_CR28) 2002; 13 Y Kitadai (6662_CR23) 1998; 152 AE Koch (6662_CR8) 1992; 258 S Yoshimatsu (6662_CR2) 1989; 171 H Yoh (6662_CR19) 2002; 82 |
| References_xml | – volume: 67 start-page: 12 year: 1999 ident: 6662_CR10 publication-title: Pathobiology doi: 10.1159/000028045 contributor: fullname: M Bar-Eli – volume: 24 start-page: 395 year: 2002 ident: 6662_CR3 publication-title: Hepatol Res doi: 10.1016/S1386-6346(02)00144-4 contributor: fullname: S Ueno – volume: 79 start-page: 185 year: 1994 ident: 6662_CR4 publication-title: Cell doi: 10.1016/0092-8674(94)90187-2 contributor: fullname: IJ Fidler – volume: 226 start-page: 54 year: 1992 ident: 6662_CR25 publication-title: Sci Am doi: 10.1038/scientificamerican0292-54 contributor: fullname: LA Liotta – volume: 23 start-page: 455 year: 1996 ident: 6662_CR21 publication-title: Hepatology doi: 10.1002/hep.510230309 contributor: fullname: M Masahiro – volume: 143 start-page: 1366 year: 1989 ident: 6662_CR11 publication-title: J Immunol doi: 10.4049/jimmunol.143.4.1366 contributor: fullname: N Mukaida – volume: 82 start-page: 109 year: 2002 ident: 6662_CR19 publication-title: Lab Invest doi: 10.1038/labinvest.3780401 contributor: fullname: H Yoh – volume: 151 start-page: 1105 year: 1997 ident: 6662_CR26 publication-title: Am J Pathol contributor: fullname: M Luca – volume: 152 start-page: 93 year: 1998 ident: 6662_CR23 publication-title: Am J Pathol contributor: fullname: Y Kitadai – volume: 324 start-page: 1 year: 1991 ident: 6662_CR7 publication-title: N Engl J Med doi: 10.1056/NEJM199101033240101 contributor: fullname: N Weidner – volume: 279 start-page: 166 year: 2000 ident: 6662_CR16 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2000.3925 contributor: fullname: A Iguchi – volume: 167 start-page: 1883 year: 1998 ident: 6662_CR14 publication-title: J Exp Med doi: 10.1084/jem.167.6.1883 contributor: fullname: K Matsushima – volume: 13 start-page: 430 year: 2002 ident: 6662_CR28 publication-title: Ann Oncol doi: 10.1093/annonc/mdf078 contributor: fullname: J Fujimoto – volume: 1 start-page: 2 year: 1989 ident: 6662_CR13 publication-title: Cytokine doi: 10.1016/1043-4666(89)91043-0 contributor: fullname: K Matsushima – volume-title: The General Rules for the Clinical and Pathological Study of Primary Liver Cancer. Fourth Edition year: 2000 ident: 6662_CR20 contributor: fullname: Liver Cancer Study Group of Japan – volume: 265 start-page: 21128 year: 1990 ident: 6662_CR12 publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)45336-1 contributor: fullname: N Mukaida – volume: 82 start-page: 4 year: 1990 ident: 6662_CR5 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/82.1.4 contributor: fullname: J Folkman – volume: 23 start-page: 755 year: 1992 ident: 6662_CR18 publication-title: Hum Pathol doi: 10.1016/0046-8177(92)90344-3 contributor: fullname: S Bosari – volume: 27 start-page: 1554 year: 1998 ident: 6662_CR22 publication-title: Hepatology doi: 10.1002/hep.510270613 contributor: fullname: ON El-Assal – volume: 171 start-page: 343 year: 1989 ident: 6662_CR2 publication-title: Radiology doi: 10.1148/radiology.171.2.2539607 contributor: fullname: S Yoshimatsu – volume: 267 start-page: 10931 year: 1992 ident: 6662_CR6 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)49853-0 contributor: fullname: J Folkman – volume: 141 start-page: 1279 year: 1992 ident: 6662_CR9 publication-title: Am J Pathol contributor: fullname: RM Strieter – volume: 258 start-page: 1798 year: 1992 ident: 6662_CR8 publication-title: Science doi: 10.1126/science.1281554 contributor: fullname: AE Koch – volume: 6 start-page: 2104 year: 2000 ident: 6662_CR24 publication-title: Clin Cancer Res contributor: fullname: K Inoue – volume: 22 start-page: 216 year: 1992 ident: 6662_CR15 publication-title: Int J Clin Lab Res doi: 10.1007/BF02591427 contributor: fullname: K Sakamoto – volume: 6 start-page: 729 year: 1986 ident: 6662_CR1 publication-title: Hepatology doi: 10.1002/hep.1840060432 contributor: fullname: K Okuda – volume: 18 start-page: 257 year: 2001 ident: 6662_CR27 publication-title: Int J Oncol contributor: fullname: J Akiba – volume: 92 start-page: 2628 year: 2001 ident: 6662_CR17 publication-title: Cancer doi: 10.1002/1097-0142(20011115)92:10<2628::AID-CNCR1616>3.0.CO;2-F contributor: fullname: D Masuya |
| SSID | ssj0017305 |
| Score | 2.1125057 |
| Snippet | Angiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the... BACKGROUNDAngiogenic factor seems necessary for the development of hepatocellular carcinoma (HCC), which is a hypervascular malignancy. This study examined the... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 800 |
| SubjectTerms | Adult Aged Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - physiopathology Cell Proliferation Chemotaxis Female Gene Expression Profiling Humans Interleukin-8 - biosynthesis Interleukin-8 - physiology Liver Neoplasms - blood supply Liver Neoplasms - physiopathology Male Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Neovascularization, Pathologic Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured |
| Title | Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/16132378 https://www.proquest.com/docview/227379842 https://search.proquest.com/docview/68624204 |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELa6i4S4IN5blocPHJCqLI2TJumx7LZqVShI7SJukeM426jbGDUJCC78dWbsPFoQCA5crCqxEtXz5ZuHPTOEvAATepiICNjPTqTlAiasKGHcAsuWccltHkmM6U6X_uJjcDF2x51O3bigvfZfJQ3XQNaYOfsP0m4eChfgN8gcRpA6jH8ldx3iu5blJs16AUYzTJh-CmqnUBim1-dOz7GFUKa2HAhhp_NZJJ6E1QlJAAOYgDG9WfaZ55VF-QGLjF_nvddl0VuowkxelVu1642yq1RdIWmm-b6x2xZnzsudYViViYM4_ryMdKx2Um7Tgm8alF1K3RK8t1xj4uY6bSPkX3iB_Z80QaVf1YZ_K5soEd-omJsMpJyv0406iGkMmtNxhzFNPLCN2yhNzo2m6L4HFM1Mh4kzWdO2a7meaf7S8Drbx29_j6UDXRz1V-3BXCy0MVq-q2Jt_lnfHrSKsj4cMB0tw_cXk_DNbDE_vKvtgiHzPRfr5B2RGwzoTzv6s3mztwWcOtB78NX_qApOwctf_fTqQ1vpNw6QNoRWd8jtyoOhIwO9u6Qjs3vk5tvqjMZ98n0PgTSgMGgE0kME0gaBtEUgRVBRg0CKCKQ1AqlKaIVACgikgEAzWSOQ7iPwAbmcjFfnU6tq82EJ0CaFxYUXSWl7IortBDWEI3B31xnGjsO4AHUd25zHwuPCdpw4AYWc-IkdxdxJAg7uykNynKlMnhAa8Jj7wgG_QTBMBYyEZAnAArzyBCayLnlZL2j4yVRzCdELhrUPYe2xJ-sg7PshrH2XnNYLHlafdx4yMPb9YeDCg543d4GPce14JlWZhybjqu92ySMjpfZFYDkzxw8e__HJp-RW-0U8IcfFrpRPyVEel880jH4AAH6yEA |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin+8+in+Human+Hepatocellular+Carcinoma+Correlates+With+Cancer+Cell+Invasion+of+Vessels+But+Not+With+Tumor+Angiogenesis&rft.jtitle=Annals+of+surgical+oncology&rft.au=Kubo%2C+Fumitake&rft.au=Ueno%2C+Shinichi&rft.au=Hiwatashi%2C+Kiyokazu&rft.au=Sakoda%2C+Masahiko&rft.date=2005-10-01&rft.pub=Springer+Nature+B.V&rft.issn=1068-9265&rft.eissn=1534-4681&rft.volume=12&rft.issue=10&rft.spage=800&rft_id=info:doi/10.1245%2FASO.2005.07.015&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=927641341 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1068-9265&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1068-9265&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1068-9265&client=summon |