Inflammatory Profile of Different Absorbable Membranes Used for Bone Regeneration: An In Vivo Study

• Published in: Biomimetics (Basel, Switzerland) Vol. 9; no. 7; p. 431
• Main Authors: Bizelli, Vinícius Ferreira, Alécio Viotto, Arthur Henrique, Delamura, Izabela Fornazari, Baggio, Ana Maira Pereira, Ramos, Edith Umasi, Faverani, Leonardo Perez, Bassi, Ana Paula Farnezi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16-07-2024
• Subjects: Angiogenesis; Biocompatibility; biomaterials; Blood vessels; Bone growth; Bone healing; bone regeneration; Bones; Calvaria; Collagen; Comparative analysis; Inflammation; Laboratory animals; Membranes; Regeneration; Software; Statistical analysis; Surgery; Brazil; United States > US; bone regeneration; angiogenesis; biomaterials
• ISSN: 2313-7673; 2313-7673
• DOI: 10.3390/biomimetics9070431

Guided bone regeneration (GBR) has become a necessary practice in implantology. Absorbable membranes have shown advantages over non-absorbable membranes, such as blood support of bone tissue. This study aimed to evaluate five collagen membranes in rat calvaria critical-size defects through a histomorphometric analysis of the inflammatory profile during the initial phase of bone repair.
A total of 72 Albinus Wistar rats were used for the study, divided into six groups, with 12 animals per group, and two experimental periods, 7 and 15 days. The groups were as follows: the CG (clot), BG (Bio-Gide
), JS (Jason
), CS (Collprotect
), GD (GemDerm
), and GDF (GemDerm Flex
).
Data showed that the BG group demonstrated an inflammatory profile with an ideal number of inflammatory cells and blood vessels, indicating a statistically significant difference between the JS and CS groups and the BG group in terms of the number of inflammatory cells and a statistically significant difference between the JS and CS groups and the GD group in terms of angiogenesis (
< 0.05).
We conclude that different origins and ways of obtaining them, as well as the thickness of the membrane, can interfere with the biological response of the material.