Abruptio placentae

Analysis of blood samples from pregnant women has shown that the mean histamine level starts to rise when the plasma ascorbic acid level falls below 1.0 mg/100 ml; it is doubled when the ascorbate level falls to 0.5 mg/100 ml and quadrupled when it falls below 0.2 mg/100 ml. The incidence of abrupti...

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Bibliographic Details
Published in:	International journal of gynecology and obstetrics Vol. 19; no. 6; p. 453
Main Authors:	Clemetson, C A, Cafaro, V
Format:	Journal Article
Language:	English
Published:	United States 01-12-1981
Subjects:	Abruptio Placentae - blood Abruptio Placentae - etiology Adult Anemia, Megaloblastic - blood Ascorbic Acid Deficiency - blood Ascorbic Acid Deficiency - complications Female Folic Acid - blood Histamine - blood Humans Pregnancy
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Summary:	Analysis of blood samples from pregnant women has shown that the mean histamine level starts to rise when the plasma ascorbic acid level falls below 1.0 mg/100 ml; it is doubled when the ascorbate level falls to 0.5 mg/100 ml and quadrupled when it falls below 0.2 mg/100 ml. The incidence of abruptio placentae was found to be seven out of 355 (or 2.0%) in women who had plasma ascorbic acid levels above 0.4 mg/100 ml and six out of 31 (19.4%) in women with plasma ascorbate levels below 0.4 mg/100 ml. This difference is highly significant. It is suggested that ascorbic acid deficiency and histamine excess play leading roles in the etiology of abruptio placentae.
ISSN:	0020-7292
DOI:	10.1016/0020-7292(81)90004-7