Multiscale 3-D + t Intracranial Aneurysmal Flow Vortex Detection

• Published in: IEEE transactions on biomedical engineering Vol. 62; no. 5; pp. 1355 - 1362
• Main Authors: Feliciani, Giacomo, Potters, Wouter V., van Ooij, Pim, Schneiders, Joppe J., Nederveen, Aart J., van Bavel, Ed, Majoie, Charles B., Marquering, Henk A.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01-05-2015
• Subjects: Algorithms; Aneurysm; Blood Flow Velocity - physiology; Computational fluid dynamics; Deconvolution; flow patterns; hemodynamics; Humans; Imaging, Three-Dimensional - methods; Intracranial Aneurysm - pathology; Intracranial Aneurysm - physiopathology; intracranial aneurysms; Kernel; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Models, Cardiovascular; multi-scale analysis; Phantoms; Phantoms, Imaging; shear layers; Three-dimensional displays; Velocity patterns; vortices; Flow patterns; velocity patterns; multiscale analysis; shear layers; vortices; intracranial aneurysms; hemodynamics
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2014.2387874

Objective: Characteristics of vortices within intracranial aneurysmal flow patterns have been associated with increased risk of rupture. The classifications of these vortex characteristics are commonly based upon qualitative scores, and are, therefore, subjective to user interpretation. We present a quantitative method for automatic time-resolved characterization of 3-D flow patterns and vortex detection within aneurysms. Methods: Our approach is based upon the combination of kernel deconvolution and Jacobian analysis of the velocity field. The deconvolution approach is accurate in detecting vortex centers but cannot discriminate between vortices and high-shear regions. Therefore, this approach is combined with analysis of the Jacobian of the velocity field. Scale-space theory is used to evaluate aneurysmal flow velocity fields at various scales. Results: The proposed algorithm is applied to computational fluid dynamics and time-resolved 3-D phase-contrast magnetic resonance imaging of aneurysmal flow. Conclusion: Results show that the proposed algorithm efficiently detects, visualizes, and quantifies vortices in intracranial aneurysmal velocity patterns at multiple scales and follows the temporal evolution of these patterns. Significance: Quantitative analysis performed with this method has the potential to reduce interobserver variability in aneurysm classification.