Celecoxib-induced cholestatic hepatotoxicity in a patient with cirrhosis

A 49-year-old man with alcoholic cirrhosis of the liver developed jaundice, fatigue, and choluria after he began taking celecoxib, 200 mg/d, for minor musculoskeletal pain. He took the drug for 15 days before presentation. The patient's history strongly suggests celecoxib-induced cholestasis.

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Bibliographic Details
Published in:	Annals of internal medicine Vol. 137; no. 1; p. 75
Main Authors:	Alegria, Paulo, Lebre, Luís, Chagas, Cristina
Format:	Journal Article
Language:	English
Published:	United States American College of Physicians 02-07-2002
Subjects:	Anti-Inflammatory Agents, Non-Steroidal - adverse effects Celecoxib Chemical and Drug Induced Liver Injury - etiology Cholestasis - chemically induced Drug therapy Humans Letters to the editor Liver cirrhosis Liver Cirrhosis, Alcoholic - complications Male Middle Aged Pyrazoles Side effects Sulfonamides - adverse effects
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Description
Summary:	A 49-year-old man with alcoholic cirrhosis of the liver developed jaundice, fatigue, and choluria after he began taking celecoxib, 200 mg/d, for minor musculoskeletal pain. He took the drug for 15 days before presentation. The patient's history strongly suggests celecoxib-induced cholestasis.
ISSN:	0003-4819 1539-3704
DOI:	10.7326/0003-4819-137-1-200207020-00030