Bacterial adherence to self-reinforced polyglycolic acid and self-reinforced polylactic acid 96 urological spiral stents in vitro

• Published in: Biomaterials Vol. 19; no. 7; pp. 677 - 681
• Main Authors: Pétas, Anssi, Vuopio-Varkila, Jaana, Siitonen, Anja, Välimaa, Tero, Talja, Martti, Taari, Kimmo
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-04-1998; Elsevier Science
• Subjects: Bacterial adherence; Bacterial Adhesion; Bacteriuria - microbiology; Bacteriuria - urine; Biocompatible Materials; Biodegradable materials; Biological and medical sciences; Enterococcus faecalis - growth & development; Escherichia coli - growth & development; Lactic Acid; Medical sciences; Microscopy, Electron, Scanning; Polyesters; Polyglycolic Acid; Polymers; Proteus mirabilis - growth & development; Pseudomonas aeruginosa - growth & development; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Stents; Technology. Biomaterials. Equipments. Material. Instrumentation; Urinary tract infection; Urinary Tract Infections - microbiology; Urinary Tract Infections - therapy; Bacterial adherence; Biodegradable materials; Urinary tract infection; Stents; Lactic acid polymer; Urethra; Biodegradability; Self reinforcement; Bacteria; Properties of materials; Biomaterial; Glycolic acid polymer; Adhesion; In vitro; Stent; Colony forming cell
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/S0142-9612(97)00171-3

Synopsis
The aim of this study was to evaluate the bacterial adherence to biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA 96) spiral stents in vitro. They are used as temporary urethral stents in urology. Gold-plated metal wire, polyurethane and latex were used as controls. Materials were incubated up to 28
days in artificial urine, after which a bacterial suspension was added. After detaching by sonication the adhesive bacteria were analysed as colony forming units (CFUs) and by scanning electron microscopy (SEM) analysis. Adhesion was more significantly correlated to stent bacterial type than to the tested material in both assays. No encrustation was seen on SR-PGA or SR-PLA 96. SR-PGA and SR-PLA 96 had no effect on the bacterial growth. In conclusion, the bacterial properties are equally or more important than the material properties in the adhesion process.