Growth charts for Mexican children with Down syndrome

• Published in: American journal of medical genetics. Part A Vol. 188; no. 4; pp. 1170 - 1183
• Main Authors: Flores Arizmendi, Karla Adney, García De La Puente, Silvestre, González Navarro, Mauricio, Bonillo Suarez, Lelia, De León Becerra, Ana Gabriela, Valderrama Hernández, Alejandro, Santos Ríos, Rubi, Altamirano Bustamante, Nelly
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-04-2022; Wiley Subscription Services, Inc
• Subjects: Adolescent; Body Height; Body Mass Index; Body Weight; Cephalometry; Child; Child, Preschool; Children; Children & youth; Cross-Sectional Studies; Down syndrome; Down Syndrome - diagnosis; Down Syndrome - epidemiology; Down's syndrome; Female; Growth Charts; Growth curves; Health care; Humans; Infant; Infant, Newborn; Male; Mexican; Physical growth; Prospective Studies; Reference Values; Mexican; Down syndrome; children; growth charts; growth curves
• ISSN: 1552-4825; 1552-4833
• DOI: 10.1002/ajmg.a.62637

We present the results of a prospective, observational, descriptive, cross‐sectional study performed on a Mexican population of 1867 children, aged 0–18 years, with Down syndrome (DS), observed between 2013 and 2019. A total of 9968 measurements of height, weight, and head circumference, as well as calculation of body mass index (BMI) were used to create growth charts and tables of percentiles. Growth curves were elaborated using Cole's LMS method. The mean weight and length at birth did not differ by sex: the weight was 2750 g for boys and 2710 g for girls (p > 0.05), and the length was 48.2 cm for boys and 47.9 cm for girls (p > 0.05). The mean final height at 18 years was different by sex: 149.6 cm for boys and 141.2 cm for girls. The average BMI at 18 years was 24.2 kg/m2 for boys and 21.9 kg/m2 for girls. In a comparison with U.S. growth charts, we find that the Mexican population has lower height and weight. These are the first growth curves for the Mexican population with DS. They can be used by health care providers to optimize preventive care by monitoring children with DS for the early identification of factors that affect individual growth.