UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions

Tyrosine kinase inhibitor treatments for chronic myeloid leukaemia based on nilotinib (NIL), dasatinib (DAS) and imatinib (IMA) have improved patient quality of life and have turned chronic myeloid leukemia from a fatal disease into a chronic disease. Dandelion is a rich source of phenolic compounds...

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Bibliographic Details
Published in:	Biomedical chromatography Vol. 33; no. 12; pp. e4674 - n/a
Main Authors:	Alzoman, Nourah Z., Maher, Hadir M., Shehata, Shereen M., Abanmy, Norah O.
Format:	Journal Article
Language:	English
Published:	England 01-12-2019
Subjects:	Animals Chromatography, High Pressure Liquid dandelion dasatinib Dasatinib - blood Dasatinib - chemistry Dasatinib - pharmacokinetics drug interactions Drug Stability Herb-Drug Interactions imatinib Imatinib Mesylate - blood Imatinib Mesylate - chemistry Imatinib Mesylate - pharmacokinetics Limit of Detection Linear Models nilotinib pharmacokinetics Plant Extracts - chemistry Plant Extracts - pharmacokinetics Plant Roots - chemistry Pyrimidines - blood Pyrimidines - chemistry Pyrimidines - pharmacokinetics Rats Reproducibility of Results Tandem Mass Spectrometry Taraxacum pharmacokinetics imatinib dasatinib drug interactions nilotinib dandelion
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