Total and Unbound Doravirine Concentrations and Viral Suppression in CSF

Abstract We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR...

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Bibliographic Details
Published in:	Clinical infectious diseases Vol. 74; no. 10; pp. 1855 - 1858
Main Authors:	Tiraboschi, Juan, Scévola, Sofia, Penchala, Sujan Dilly, Challenger, Elisabeth, Else, Laura, Prieto, Paula, Saumoy, Maria, Imaz, Arkaitz, Silva-Klug, Ana, Niubó, Jordi, Soriano, Irene, Khoo, Saye, Rigo-Bonin, Raul, Podzamczer, Daniel
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 30-05-2022
Subjects:	CNS Doravirine unbound concentrations HIV CSF
Online Access:	Get full text
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Summary:	Abstract We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciab835