Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications

• Published in: Nanomedicine (London, England) Vol. 16; no. 23; pp. 2039 - 2059
• Main Authors: Mohapatra, Debadatta, Alam, Md. Bayazeed, Pandey, Vivek, Pratap, Ravi, Dubey, Pawan K, Parmar, Avanish S, Sahu, Alakh N
• Format: Journal Article
• Language: English
• Published: Future Medicine Ltd 01-10-2021
• Subjects: bioimaging; carbon dots; green synthesis; metal sensing; radical scavenging
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2021-0190

This work aimed to develop
stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications.
The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility,
cellular imaging, free radical scavenging and metal sensing ability.
The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe
sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability.
The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications.