Mapping of the SWAP70 gene to mouse chromosome 7 and human chromosome 11p15

• Published in: Immunogenetics (New York) Vol. 51; no. 1; pp. 16 - 19
• Main Authors: Masat, L, Liddell, R A, Mock, B A, Kuo, W L, Jessberger, R, Wabl, M, Morse, 3rd, H C
• Format: Journal Article
• Language: English
• Published: United States 01-01-2000
• Subjects: Animals; chromosome 11; chromosome 7; Chromosomes, Human, Pair 11 - genetics; DNA-Binding Proteins - genetics; Guanine Nucleotide Exchange Factors; Haplotypes; Humans; In Situ Hybridization, Fluorescence; Mice; Mice, Inbred BALB C; Microsatellite Repeats; Minor Histocompatibility Antigens; Nuclear Proteins - genetics; Physical Chromosome Mapping; Polymorphism, Restriction Fragment Length; SWAP70 gene
• ISSN: 0093-7711; 1432-1211
• DOI: 10.1007/s002510050003

The protein SWAP-70 was isolated as part of a DNA recombination complex in B lymphocytes, where it is predominantly expressed. In resting B cells, SWAP-70 is found in the cytoplasm; upon B-cell activation, it is transported both into the nucleus and to the cell membrane, where it is associated with the B-cell receptor complex and may play a role in signal transduction. In the nucleus, its involvement in heavy-chain class switch recombination has been suggested. In this report, using restriction fragment length polymorphism, simple sequence length polymorphism, and fluorescence in situ hybridization, we map the chromosomal localization of the mouse and the human genes to syntenic regions of mouse mid Chromosome (Chr) 7 and human Chr 11p15.