Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats

1 Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of catecholamine biosynthetic enzymes were examined in adrenal medulla of unstressed control and chronic unpredictable mild stressed rats. 2 Maprotiline did not ch...

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Bibliographic Details
Published in:	Autonomic & autacoid pharmacology Vol. 30; no. 4; p. 213
Main Authors:	Spasojevic, N, Gavrilovic, L, Dronjak, S
Format:	Journal Article
Language:	English
Published:	England 01-10-2010
Subjects:	Adrenal Medulla - drug effects Adrenal Medulla - enzymology Adrenal Medulla - metabolism Adrenergic Uptake Inhibitors - pharmacology Adrenergic Uptake Inhibitors - therapeutic use Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Dopamine beta-Hydroxylase - genetics Dopamine beta-Hydroxylase - metabolism Epinephrine - metabolism Fluoxetine - pharmacology Fluoxetine - therapeutic use Gene Expression Regulation, Enzymologic - drug effects Male Maprotiline - pharmacology Maprotiline - therapeutic use Norepinephrine - metabolism Phenylethanolamine N-Methyltransferase - genetics Phenylethanolamine N-Methyltransferase - metabolism Random Allocation Rats Rats, Wistar RNA, Messenger - metabolism Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use Stress, Physiological - drug effects Stress, Psychological - drug therapy Stress, Psychological - enzymology Stress, Psychological - metabolism Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism
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