Metabolic Fate of Clonidine (I)：Absorption, Distribution and Excretion in Rats, Dogs and Monkeys after Subcutaneous Administration of Clonidine

After a single subcutaneous administration of 14C-clonidine at a dose of 1 mg/kg (principally) to rats, dogs and a monkey, the absorption, distribution and excretion of radioactivity were investigated. 1. In the male rats, the radioactivity level in plasma reached a maximum (Cmax) at 2 hr and then d...

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Bibliographic Details

Published in:	Xenobiotic metabolism and disposition Vol. 11; no. 4; pp. 375 - 385
Main Authors:	YAMAHATA, Tohru, MINAKI, Yasuo, NISHIKAWA, Hitoshi, ESUMI, Yoshio, JIN, Yoshitaka, TAKAO, Atsushi, MASHIKO, Toshiyuki, ICHIGE, Kazumi, YAMASHITA, Kumiko, OHTSUBO, Miwa, HORI, Katsuyuki
Format:	Journal Article
Language:	English Japanese
Published:	Japanese Society for the Study of Xenobiotics 1996
Online Access:	Get full text
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