In vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions

Interactions of a vasodilator, isosorbide dinitrate (ISDN), with the parent α-, β- and γ-cyclodextrins (α-, β- and γ-CDs) and 2-hydroxypropyl-α- and -β- and γ-CDs (HP-α- and -β- and -γ-CDs) and the dissolution properties of ISDN/β-CD complexes were investigated. The effects of HP-β-CD on the in vitr...

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Bibliographic Details
Published in:	Journal of inclusion phenomena and macrocyclic chemistry Vol. 96; no. 1-2; pp. 137 - 143
Main Authors:	Zao, Katsutoshi, Ishiguro, Takako, Iohara, Daisuke, Anraku, Makoto, Seo, Hakaru, Irie, Tetsumi, Uekama, Kaneto, Hirayama, Fumitoshi
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-02-2020 Springer Nature B.V
Subjects:	Chemistry Chemistry and Materials Science Complexation Crystallography and Scattering Methods Cyclodextrins Dissolution Food Science Holes ISDN Oleic acid Organic Chemistry Original Article Penetration Stoichiometry Isosorbide dinitrate Cyclodextrin Skin permeation Transdermal delivery Size dependency Dissolution Inclusion complex
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