Ag2WO4 nanoparticles radiolabeled with technetium-99m: a potential new tool for tumor identification and uptake

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 323; no. 1; pp. 51 - 59
• Main Authors: Santos, Carla Júnia, Filho, Francisco Moura, Campos, Fernanda Lapa, Ferreira, Carolina de Aguiar, de Barros, André Luís Branco, Soares, Daniel Crístian Ferreira
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2020; Springer Nature B.V
• Subjects: Biomedical materials; Chemistry; Chemistry and Materials Science; Diagnostic Radiology; Hadrons; Heavy Ions; In vivo methods and tests; Inorganic Chemistry; Muscles; Nanomaterials; Nanoparticles; Nuclear Chemistry; Nuclear Physics; Physical Chemistry; Technetium; Technetium isotopes; Tumors; nanoparticles; Ag; Tc]–Ag; tumor probe; WO; [; tumor-bearing mice biodistribution
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-019-06955-2

Silver tungstate nanoparticles have been presenting attractive characteristics that could allow its usage in the biomedical sciences. In this study, Ag
2
WO
4
nanoparticles with an average size of 242 nm were obtained and radiolabeled with technetium-99m with high labeling-yield as well as high stability. Biodistribution studies were carried out in healthy and tumor-bearing mice to determine the nanoparticle’s in vivo behavior. The results revealed an important tumor-to-muscle ratio, reaching values above than 1.5, demonstrated the ability of this nanomaterial in accumulating preferentially in tumor tissue. All results together, converge to consider the Ag
2
WO
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nanoparticles as a potential system against cancer and a potential new radiolabeled probe for tumor identification and uptake.