Rapid Screening Method in the Identification of 17 Adulterants in Dietary Supplements

There are several promises on the market related to the consumption of dietary supplements such as health benefits, improvements in body performance, combating aging and weight loss. One of the risks to consumers of dietary supplements is related to adulteration by substances that can cause adverse...

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Published in:	Chromatographia Vol. 84; no. 3; pp. 267 - 274
Main Authors:	dos Santos, Julia Rodrigues Martins Pastor, Junior, Jorge Guerra Mendes, Albert, André Luis Mazzei, Leandro, Katia Christina
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2021 Springer Nature B.V
Subjects:	Adulterants Analytical Chemistry Chemistry Chemistry and Materials Science Chromatography Dietary supplements Diuretics Fourier transforms Laboratory Medicine Mass spectrometry Molecular absorption NMR NMR spectroscopy Nuclear magnetic resonance Original Pharmacy Proteomics Screening Weight loss Diuretics Diode-array detection Stimulants High-performance liquid chromatography Anorexigenics Dietary supplements
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Abstract	There are several promises on the market related to the consumption of dietary supplements such as health benefits, improvements in body performance, combating aging and weight loss. One of the risks to consumers of dietary supplements is related to adulteration by substances that can cause adverse health reactions. The aim of this study was to develop a qualitative screening method for the detection of substances with pharmacological properties: stimulants, anorectic and diuretics in dietary supplement samples. A spectral database, using the following analytical techniques: molecular absorption spectroscopy in the UV and Fourier transform infrared (FTIR) regions, nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (MS), was created to compare the chromatograms of the samples and the standards searched. Two columns were tested, Ace ® and Phenomenex ® , and the result was compared for the screening methods developed separately for each column. The Phenomenex ® column was chosen for the sample analysis using HPLC–DAD.
AbstractList	There are several promises on the market related to the consumption of dietary supplements such as health benefits, improvements in body performance, combating aging and weight loss. One of the risks to consumers of dietary supplements is related to adulteration by substances that can cause adverse health reactions. The aim of this study was to develop a qualitative screening method for the detection of substances with pharmacological properties: stimulants, anorectic and diuretics in dietary supplement samples. A spectral database, using the following analytical techniques: molecular absorption spectroscopy in the UV and Fourier transform infrared (FTIR) regions, nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (MS), was created to compare the chromatograms of the samples and the standards searched. Two columns were tested, Ace ® and Phenomenex ® , and the result was compared for the screening methods developed separately for each column. The Phenomenex ® column was chosen for the sample analysis using HPLC–DAD. There are several promises on the market related to the consumption of dietary supplements such as health benefits, improvements in body performance, combating aging and weight loss. One of the risks to consumers of dietary supplements is related to adulteration by substances that can cause adverse health reactions. The aim of this study was to develop a qualitative screening method for the detection of substances with pharmacological properties: stimulants, anorectic and diuretics in dietary supplement samples. A spectral database, using the following analytical techniques: molecular absorption spectroscopy in the UV and Fourier transform infrared (FTIR) regions, nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (MS), was created to compare the chromatograms of the samples and the standards searched. Two columns were tested, Ace® and Phenomenex®, and the result was compared for the screening methods developed separately for each column. The Phenomenex® column was chosen for the sample analysis using HPLC–DAD.
Author	Leandro, Katia Christina dos Santos, Julia Rodrigues Martins Pastor Junior, Jorge Guerra Mendes Albert, André Luis Mazzei
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SubjectTerms	Adulterants Analytical Chemistry Chemistry Chemistry and Materials Science Chromatography Dietary supplements Diuretics Fourier transforms Laboratory Medicine Mass spectrometry Molecular absorption NMR NMR spectroscopy Nuclear magnetic resonance Original Pharmacy Proteomics Screening Weight loss
Title	Rapid Screening Method in the Identification of 17 Adulterants in Dietary Supplements
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