The aminoestrogen prolame increases recognition memory and hippocampal neuronal spine density in aged mice

The aging brain shows biochemical and morphological changes in the dendrites of pyramidal neurons from the limbic system associated with memory loss. Prolame (N‐(3‐hydroxy‐1,3,5 (10)‐estratrien‐17β‐yl)‐3‐hydroxypropylamine) is a non‐feminizing aminoestrogen with antithrombotic activity that prevents...

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Bibliographic Details
Published in:	Synapse (New York, N.Y.) Vol. 71; no. 10; pp. e21987 - n/a
Main Authors:	Diaz, Alfonso, Treviño, Samuel, Vázquez‐Roque, Rubén, Venegas, Berenice, Espinosa, Blanca, Flores, Gonzalo, Fernández‐G, Juan Manuel, Montaño, Luis F., Guevara, Jorge
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-10-2017
Subjects:	aging Alzheimer Cognitive ability dendrites Dendritic spines Dentate gyrus estrogens Exploration Granule cells Hippocampal plasticity Hippocampus Inflammation Limbic system Locomotor activity Memory Morphology Motor task performance Neurodegenerative diseases novel object recognition task Nucleus accumbens Oxidative stress Pattern recognition plasticity Pyramidal cells Rodents Spiny neurons dendrites estrogens plasticity novel object recognition task aging Alzheimer
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