Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents

There is a need to find novel oestrogen receptor (ER) ligands that antagonize oestrogen action in the reproductive tissues and would therefore have therapeutic potential in oestrogen-dependent tumours. We tested novel ER ligands in both breast and endometrial cells to profile agonism/antagonism in t...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 47; no. 5; pp. 437 - 443
Main Authors:	NUTTALL, Mark E, PENDRAK, Israil, EMERY, John G, NADEAU, Daniel P, FISHER, Paul W, NICHOLSON, Thema A, YUAN ZHU, SUVA, Larry J, KINGSBURY, William D, GOWEN, Maxine
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-05-2001
Subjects:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Breast Neoplasms - metabolism Cell Division - drug effects Chemotherapy Endometrium - cytology Endometrium - drug effects Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - pharmacology Female Fulvestrant Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Neoplasms, Hormone-Dependent - metabolism Pharmacology. Drug treatments Receptors, Estrogen - drug effects Tumor Cells, Cultured - drug effects Antineoplastic agent Human Cell proliferation Ligand Antiestrogen Estrogen Chemical structure Malignant tumor In vitro Biological activity Mammary gland diseases Binding capacity Analog Established cell line Antagonist Mammary gland Sex steroid hormone Tumor cell Endometrium Hormonal receptor
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