MRI reveals multiple reversible cerebral lesions in an attack of acute intermittent porphyria

A 20-year-old woman had an attack of acute intermittent porphyria (AIP) with seizures and hallucinations. MRI revealed multiple lesions in both hemispheres. Both the cerebral clinical abnormalities and the MRI lesions resolved following treatment. These findings suggest that a vascular mechanism may...

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Bibliographic Details
Published in:	Neurology Vol. 41; no. 8; pp. 1300 - 1302
Main Authors:	KING, P. H, BRAGDON, A. C
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-08-1991
Subjects:	Acute Disease Adult Biological and medical sciences Brain - pathology Female Hallucinations - etiology Humans Magnetic Resonance Imaging Medical sciences Metabolic diseases Other metabolic disorders Pigments (porphyrias, hyperbilirubinemias...) Porphyrias - complications Porphyrias - diagnosis Porphyrias - pathology Quadriplegia - etiology Seizures - etiology Human Porphyria Nervous system diseases Hallucination Pathogenesis Exploration Metabolic diseases Nuclear magnetic resonance imaging Case study Convulsion Ischemia Porphyrin Pigments Adult Complication Cerebrovascular disease Brain (vertebrata)
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Summary:	A 20-year-old woman had an attack of acute intermittent porphyria (AIP) with seizures and hallucinations. MRI revealed multiple lesions in both hemispheres. Both the cerebral clinical abnormalities and the MRI lesions resolved following treatment. These findings suggest that a vascular mechanism may underlie the pathogenesis of cerebral dysfunction in AIP.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.41.8.1300