Hemophilia B acquired after cadaveric liver transplantation: a case report

• Published in: Journal of surgical case reports Vol. 2022; no. 9
• Main Authors: Machado e Silva Gomide, Larissa, Weihermann, Viktoria, de Oliveira, Isabella Corrêa, Nissel, Maria Alice Zarate, Valejo, Igor Raphael Mathias, da Silva Wolff, Lucas, de Aguiar, Alan Junior, Verona, Dunia, Degraf, Ygor, de Carvalho Arouca, Julianna Storace, Barros Sanches, João Paulo, Cabral, Rodrigo Rezende Silva, Kampa, Katia Cristina, de Freitas, Alexandre Coutinho Teixeira, Tefili, Nertan Luiz
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01-09-2022
• Subjects: Case Report
• ISSN: 2042-8812; 2042-8812
• DOI: 10.1093/jscr/rjac393

Abstract
Hemophilia B is a recessive hereditary disease, and manifestations result from coagulation factor IX deficiency. Although improbable, as factor IX is produced exclusively in the liver, the possibility of developing the disease after transplantation represents an infrequent but potentially morbid complication. Standard laboratory tests may be insufficient to determine the probability of transmission of this pathology. This report describes the case of a patient who developed hemophilia B after liver transplantation whose donor had no prior knowledge of the disease.