Incidence and Long-Term Outcomes of Biliary Tract Cancers in Olmsted County, Minnesota from 1976 to 2018

• Published in: Cancers Vol. 16; no. 15; p. 2720
• Main Authors: Nwankwo, Jr, Eugene C, Guta, Amerti, Cao, Scarlett S, Yang, Ju Dong, Abdalla, Abubaker, Taha, Wesam, Larson, Joseph J, Yin, Jun, Gores, Gregory J, Cleary, Sean P, Roberts, Lewis R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-08-2024
• Subjects: Age; Alcohol use; Ampulla of Vater; Bile ducts; Biliary tract; Biliary tract diseases; Cancer; Cancer patients; Cancer therapies; Care and treatment; Censuses; Chemotherapy; Cholangiocarcinoma; Cholangitis; Development and progression; Epidemiology; Family medical history; Gallbladder cancer; Gallstones; Hepatitis; Liver cirrhosis; Medical prognosis; Medical records; Missing data; Mortality; Oncology, Experimental; Patients; Population; Prognosis; Radiation therapy; Risk factors; Strategic planning (Business); Survival; Minnesota; United States > US; epidemiology; extrahepatic cholangiocarcinoma; incidence; intrahepatic cholangiocarcinoma; survival
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16152720

Biliary tract cancers, including cholangiocarcinoma, gallbladder, and ampulla of Vater cancers, rank second among hepatobiliary cancers, known for their poor prognoses. The United States has witnessed a notable increase in intrahepatic cholangiocarcinoma incidence. This study examines the incidence and survival outcomes of biliary tract cancers in Olmsted County, Minnesota from 1976 to 2018. Using data from the Rochester Epidemiology Project (REP), residents aged 20 and above were analyzed across four eras. Incidence rates were calculated and adjusted for age and sex, and temporal trends were assessed using Poisson regression. Intrahepatic cholangiocarcinoma exhibited a significant escalation in incidence rates over time, while gallbladder cancers showed a decline among women. Median survival times for biliary tract cancers notably improved. These findings confirm the rising incidence of intrahepatic cholangiocarcinoma and suggest improving survival rates. Nevertheless, the overall prognosis for biliary tract cancers remains very poor, emphasizing the continual need for enhanced management strategies and further research.