Culprit only or multivessel percutaneous coronary interventions in patients with ST-segment elevation myocardial infarction and multivessel disease

• Published in: EuroIntervention Vol. 8; no. 4; pp. 456 - 464
• Main Authors: JENSEN, Lisette Okkels, THAYSSEN, Per, TOFT SØRENSEN, Henrik, THUESEN, Leif, KÖRMENDINE FARKAS, Dóra, HOUGAARD, Mikkel, JUHL TERKELSEN, Christian, TILSTED, Hans-Henrik, MAENG, Michael, JUNKER, Anders, LASSEN, Jens Flensted, HORVATH-PUHO, Erzsébet
• Format: Journal Article
• Language: English
• Published: Toulouse Société Europa Edition 01-08-2012
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Cohort Studies; Coronary heart disease; Denmark; Diseases of the cardiovascular system; Electrocardiography; Female; Heart; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - mortality; Myocardial Infarction - therapy; Myocarditis. Cardiomyopathies; Percutaneous Coronary Intervention - methods; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Registries; Regression Analysis; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Treatment Outcome; Vascular Diseases - mortality; Vascular Diseases - therapy; Denmark; Human; Myocardial infarction; Primary PCl; Atherectomy; Disease; Angioplasty; Coronary artery; Instrumentation therapy; Cardiovascular disease; Patient; Multivessel disease; Coronary heart disease; Myocardial disease; Stent; Percutaneous route; ST elevation; Primary; ST-segment elevation myocardial infarction
• ISSN: 1774-024X; 1969-6213
• DOI: 10.4244/EIJV8I4A72

In patients with ST-segment elevation myocardial infarction (STEMI), timely reperfusion with primary percutaneous coronary intervention (PPCI) is the preferred treatment. However, it remains unclear whether the optimal strategy is complete revascularisation or culprit vessel PPCI only.
From January 2002 to June 2009 all patients treated with PPCI were identified from the Western Denmark Heart Registry. We examined mortality according to timing of multivessel PCI: acute procedure, staged procedure during the index hospitalisation, or staged procedure performed within 60 days. The hazard ratio (HR) for death was estimated using a time-dependent Cox regression model, with time of PCI for the non-culprit lesion as the time-dependent variable. The study cohort consisted of 5,944 patients, of whom 4,770 (80%) had single-vessel disease and 1,174 (20%) had multivessel PCI within 60 days. Among 354 (30.2%) patients with acute multivessel PCI, 194 (16.5%) patients with multivessel PCI during the index hospitalisation, and 626 (53.3%) patients with multivessel PCI within 60 days after the index hospitalisation, the adjusted HRs for one-year mortality were 1.53 (95% confidence interval (CI): 1.07-2.18), 0.60 (95% CI: 0.28-1.26), and 0.28 (95% CI: 0.14-0.54), respectively, compared to patients with single vessel disease.
Acute multivessel PCI in patients with STEMI was associated with increased mortality.