Antineurofilament antibodies in postpolio syndrome

• Published in: Neurology Vol. 51; no. 4; pp. 1193 - 1195
• Main Authors: DRORY, V. E, SHAPIRA, A, KORCZYN, A. D, SHAVIT, S, KUSHNIR, M, MICHAELSON, D. M, CHAPMAN, J
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-10-1998
• Subjects: Adult; Amyotrophic Lateral Sclerosis - immunology; Autoantibodies - blood; Biological and medical sciences; Cholinergic Fibers - immunology; Female; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Neurofilament Proteins - immunology; Postpoliomyelitis Syndrome - immunology; Spinal Cord - cytology; Spinal Cord - immunology; Tropical medicine; Viral diseases; Viral diseases of the nervous system; Human; Nervous system diseases; Antibody; Pathogenesis; Acute; Amyotrophic lateral sclerosis; Acute anterior poliomyelitis; Infection; Neurofilament; Immunological investigation; Viral disease; Central nervous system disease; Complication; Degenerative disease; Spinal cord disease; Comparative study
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/WNL.51.4.1193

We determined the levels of antineurofilament antibodies in 29 patients with postpolio syndrome (PPS), 26 stable postpolio (PP) patients, 22 patients with ALS, and 20 normal controls (NCs). Patients with PPS had higher antibody levels to cholinergic neurofilaments than did all other groups. PP patients and those with ALS had antibody levels similar to those of NCs. The antibody binding level showed no relation to the age of the patients, duration of disease, or motor score.