A Molecular Basis for Innovation in Drug Excipients

Excipients are ubiquitous in drug formulation, ensuring that active ingredient drugs are properly released on dosing, retain their properties over time, and are palatable, among other roles. Despite their crucial roles, surprisingly little is known about their systemic availability and activities on...

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Bibliographic Details
Published in:	Clinical pharmacology and therapeutics Vol. 101; no. 3; pp. 320 - 323
Main Authors:	Irwin, JJ, Pottel, J, Zou, L, Wen, H, Zuk, S, Zhang, X, Sterling, T, Shoichet, BK, Lionberger, R, Giacomini, KM
Format:	Journal Article
Language:	English
Published:	United States 01-03-2017
Subjects:	Chemistry, Pharmaceutical - organization & administration Databases, Factual Drugs, Generic Excipients - chemistry Humans United States United States Food and Drug Administration
Online Access:	Get full text
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Summary:	Excipients are ubiquitous in drug formulation, ensuring that active ingredient drugs are properly released on dosing, retain their properties over time, and are palatable, among other roles. Despite their crucial roles, surprisingly little is known about their systemic availability and activities on molecular targets. Here we review key excipient properties, introduce a public‐accessible database that enumerates and categorizes them, and sketch a strategy for exploring their possible direct actions on molecular targets.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0009-9236 1532-6535
DOI:	10.1002/cpt.458