Guess what: Chronic 13q14.3+/CD5−/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23− mantle cell lymphoma in lymph nodes

• Published in: Cytometry. Part B, Clinical cytometry Vol. 51B; no. 1; pp. 41 - 44
• Main Authors: Lima, Margarida, Pinto, Luísa, Dos Anjos Teixeira, Maria, Canelhas, Áurea, Mota, Alexandra, Cabeda, José Manuel, Silva, Cidália, Queirós, Maria Luís, Fonseca, Sónia, Santos, Ana Helena, Brochado, Paulo, Justiça, Benvindo
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01-01-2003
• Subjects: 13q; Aged; Aged, 80 and over; B cells; biclonal; CD5 Antigens - analysis; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 14; chronic lymphocytic leukemia; Flow Cytometry; fluorescence in situ hybridization; Humans; leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - complications; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymph Nodes - pathology; lymphoma; Lymphoma, Mantle-Cell - complications; Lymphoma, Mantle-Cell - genetics; Lymphoma, Mantle-Cell - pathology; Male; mantle cell; Receptors, IgE - analysis; t(11;14); Translocation, Genetic
• ISSN: 1552-4949; 1552-4957
• DOI: 10.1002/cyto.b.10005

We report a case of a patient with two B‐cell lymphoproliferative disorders: CD5−/CD23+ B‐cell chronic lymphocytic leukemia and CD5+/CD23− mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction–based molecular studies. The B‐cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes. Cytometry Part B (Clin. Cytometry) 51B:41–44, 2003. © 2002 Wiley‐Liss, Inc.