Macrovipera lebetina obtusa Snake Venom as a Modulator of Antitumor Effect in S-180 Sarcoma Mouse Model

Macrovipera lebetina obtusa (MLO) is a venomous snake endemic to Middle East. Here we describe the therapeutic potential of the MLO snake venom. In S-180 sarcoma-bearing mouse model, we showed that the MLO snake venom inhibits tumour growth by 50%. In human dermal microvascular endothelial cells (HM...

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Bibliographic Details
Published in:	Molecular biology (New York) Vol. 55; no. 3; pp. 405 - 412
Main Authors:	Ghazaryan, N., Movsisyan, N., Macedo, J. C., Vaz, S., Ayvazyan, N., Pardo, L., Logarinho, E.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-05-2021 Springer Nature B.V
Subjects:	Angiogenesis Antitumor activity Apoptosis Biochemistry Biomedical and Life Sciences Caspase-8 Cell death Chorioallantoic membrane Cytotoxicity Delta cells Endothelial cells Fibroblast growth factor 2 Human Genetics Life Sciences Macrovipera lebetina obtusa Microvasculature Molecular Cell Biology Necroptosis Poisons Sarcoma Snakes Tumors Vascular endothelial growth factor Venom Venomous snakes snake venom sarcoma angiogenesis necroptosis
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