Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids

• Published in: Russian journal of bioorganic chemistry Vol. 44; no. 6; pp. 740 - 744
• Main Authors: Kazakova, O. B., Smirnova, I. E., Baltina, L. A., Boreko, E. I., Savinova, O. V., Pokrovskii, A. G.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-11-2018; Springer Nature B.V
• Subjects: Acids; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Derivatives; HIV; Human immunodeficiency virus; Influenza; Life Sciences; Organic Chemistry; Terpenes; Viruses; betulin; quinopimaric acid; diterpenoids; acylates; antiviral activity; triterpenoids
• ISSN: 1068-1620; 1608-330X
• DOI: 10.1134/S1068162018050059

The paper reports on the synthesis of a series of acyl derivatives of betulin and dihydroquinopimaric acid and the study of their antiviral activity against influenza A virus (H7N1), herpes simplex virus type 1 (HSV-1), ECHO 6, and HIV-1 in comparison with the activity of the previously obtained acylates and original terpenoids. It has been demonstrated that acylated betulin and betulinic acid show no advantage in inhibiting the reproduction of all the tested viruses compared with the betulic acid, while structural modifications at positions C3 and C28 of the triterpene core led to some changes in the spectrum of antiviral activity. Modification of dihydroquinopimaric acid at position C4 increased the activity of this compound against influenza virus A (H7N1).