Square Wave Voltammetric Determination of Rasagiline Mesylate on Hanging Mercury Drop Electrode and its application in Dosage Form and Biological Fluids

• Published in: International journal of electrochemical science Vol. 11; no. 6; pp. 4802 - 4811
• Main Authors: Habib, Ibrahim H.I., Rizk, Mohamed, Mohamed, Dalia, Mowaka, Shereen, El-Eryan, Rasha Th
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-06-2016
• Subjects: acetylene group; Hanging Mercury Drop Electrode; Rasagiline mesylate; Square Wave Voltammetry; acetylene group; Rasagiline mesylate; Square Wave Voltammetry; Hanging Mercury Drop Electrode
• ISSN: 1452-3981; 1452-3981
• DOI: 10.20964/2016.06.64

A new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries ± relative standard deviation of 95.46 ± 3.7 6 and in spiked human plasma with 94.3 ± 2.8 9%, respectively.