Improving the Analytical Performances of the Ibuprofen Voltammetric Determination at Bare Graphite Electrode Using Semi-Derivative Linear Sweep Voltammetry

• Published in: International journal of electrochemical science Vol. 17; no. 6; p. 220668
• Main Authors: Stoytcheva, Margarita, Zlatev, Roumen, Velkova, Zdravka, Gochev, Velizar, Valdez, Benjamin, Kirova, Gergana, Hristova, Yana
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-06-2022
• Subjects: graphite electrode; ibuprofen; semi-derivative voltammetry; graphite electrode; ibuprofen; semi-derivative voltammetry
• ISSN: 1452-3981; 1452-3981
• DOI: 10.20964/2022.06.61

In this work, a bare graphite electrode was applied for the simple and cost-effective ibuprofen determination. Analytical performances improvement was achieved taking advantage of the semi-derivative processing of the signal obtained by linear sweep voltammetry. The semi-differentiation led to transformation of the asymmetric and broad ibuprofen current peaks into much more symmetrical, bell-shaped and detectable semi-derivative signals, as well as to sensitivity enhancement. Under the optimized conditions (3 min accumulation time and pH 4.5) the peak current varied with ibuprofen concentrations in two linear ranges: from 2 μmol L-1 to 100 μmol L-1 and from 100 μmol L-1 to 500 μmol L-1 with a limit of detection of 0.6 μmol L-1 (S/N=3). The method was successfully applied for the determination of ibuprofen in pharmaceutical formulations with satisfactory recovery values (99.2%–101.6%). The proposed sensor also demonstrated good selectivity and reproducibility.