Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

• Published in: Placenta (Eastbourne) Vol. 130; pp. 42 - 45
• Main Authors: Floriano, Juliana Ferreira, Barbosa, Angélica Mércia Pascon, de Oliveira, Rafael Guilen, Vega, Sofía, Catinelli, Bruna Bologna, Garcia, Gabriela Azevedo, Reyes, David Rafael, Sobrevia, Luis, Rudge, Marilza Vieira Cunha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-12-2022
• Subjects: Animals; Blood Glucose; Diabetes Mellitus, Experimental - therapy; Dogs; Female; Male; Pregnancy; Rats; Streptozocin - adverse effects
• ISSN: 0143-4004; 1532-3102
• DOI: 10.1016/j.placenta.2022.11.002

Induction of diabetes mellitus by streptozotocin (STZ) in rats at birth is of high mortality and low success rate when male puppies are separated from females, prioritizing females breastfeeding. Cross-parental care of the entire litter and SZT-induced diabetes up to 12 h post-birth become with high success rate, low animal death, and females with glycaemia >140 mg/dL on the 90 postnatal day. Cross-parental care is more effective in STZ-induction of diabetes, which is maintained during pregnancy (diabetes in pregnancy), than the conventional protocol of male separation at birth.
•Conventional protocols (females separated from males) are of low success in inducing diabetes.•Cross-parental care of the entire litter (females + males) is of diabetes high success rate.•Cross-parental care of the entire litter abolished female's maternal rejection.