Prostanoid receptors in hyperfiltration‐mediated glomerular injury: Novel agonists and antagonists reveal opposing roles for EP2 and EP4 receptors

Increased fluid‐flow shear stress (FFSS) contributes to hyperfiltration‐induced podocyte and glomerular injury resulting in progression of chronic kidney disease (CKD). We reported that increased FFSS in vitro and in vivo upregulates PGE2 receptor EP2 (but not EP4 expression), COX2‐PGE2‐EP2 axis, an...

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Bibliographic Details

Published in:	The FASEB journal Vol. 36; no. 10; pp. e22559 - n/a
Main Authors:	Srivastava, Tarak, Garola, Robert E., Zhou, Jianping, Boinpelly, Varun C., Priya, Lakshmi, Ali, Mohammed Farhan, Rezaiekhaligh, Mohammad H., Heruth, Daniel P., Novak, Jan, Alon, Uri S., Joshi, Trupti, Jiang, Yuexu, McCarthy, Ellen T., Savin, Virginia J., Johnson, Mark L., Sharma, Ram, Sharma, Mukut
Format:	Journal Article
Language:	English
Published:	01-10-2022
Subjects:	fluid‐flow shear stress glomerular filtration barrier glomerular hemodynamics hyperfiltration podocytes
Online Access:	Get full text
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