Highly multiplexed design of an allosteric transcription factor to sense new ligands

Allosteric transcription factors (aTF) regulate gene expression through conformational changes induced by small molecule binding. Although widely used as biosensors, aTFs have proven challenging to design for detecting new molecules because mutation of ligand-binding residues often disrupts alloster...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 10001 - 18
Main Authors:	Nishikawa, Kyle K., Chen, Jackie, Acheson, Justin F., Harbaugh, Svetlana V., Huss, Phil, Frenkel, Max, Novy, Nathan, Sieren, Hailey R., Lodewyk, Ella C., Lee, Daniel H., Chávez, Jorge L., Fox, Brian G., Raman, Srivatsan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19-11-2024 Nature Publishing Group Nature Portfolio
Subjects:	49 49/23 631/1647/1888 631/326/2522 631/45/612/822 631/61/338/469 Allosteric properties Antimalarial agents Binding Biosensors Design Design factors Flavonoids Gene expression Humanities and Social Sciences Ligands Methionine multidisciplinary Naltrexone Naringenin Quinine Science Science (multidisciplinary) Sensors Transcription factors
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