High-sensitivity biomedical sensor based on photoacoustic and cavity enhanced absorption spectroscopy with a new software platform for breath analysis

• Published in: Applied optics. Optical technology and biomedical optics Vol. 60; no. 7; p. 2093
• Main Authors: Bayrakli, Ismail, Akman, Hatice, Sari, Filiz
• Format: Journal Article
• Language: English
• Published: United States 01-03-2021
• Subjects: Biomarkers - analysis; Biosensing Techniques; Breath Tests - methods; Environmental Monitoring - instrumentation; Photoacoustic Techniques - methods; Sensitivity and Specificity; Software; Spectrum Analysis - methods
• ISSN: 2155-3165
• DOI: 10.1364/AO.417569

An easy-to-use highly sensitive sensor is reported for trace gas analysis. A near-infrared fiber-coupled external cavity diode laser in combination with a photoacoustic spectroscopy cell and a cavity enhanced absorption spectroscopy cell is used for analysis of trace gases. A software platform for direct absorption and wavelength modulation spectroscopy is developed in order to identify and quantify the molecules and to achieve a higher signal-to-noise ratio. Considering all of these features, the main advantage of our system is to analyze two different samples simultaneously and quickly. Trace gas measurement is assessed, and a detection limit of 1.5 ppb at 6528.76
for ammonia is demonstrated. Furthermore, the sensor with our software platform can be easily used outside of the laboratory, for example, in hospitals.