Pathways of paracetamol absorption from layered excipient suppositories: artificial intelligence approach

When studying paracetamol availability after rectal administration, the differences between slower and faster release suppositories were discovered. Approach with modelling and simulation of compartment-based models was used to explore the differences. A study of paracetamol from layered excipient s...

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Bibliographic Details
Published in:	European journal of drug metabolism and pharmacokinetics Vol. 28; no. 1; pp. 31 - 40
Main Authors:	BELIC, A, GRABNAR, I, KARBA, R, MRHAR, A
Format:	Journal Article
Language:	English
Published:	Genève Médecine et hygiène 01-01-2003
Subjects:	Acetaminophen - pharmacokinetics Adult Algorithms Analgesics Analgesics, Non-Narcotic - pharmacokinetics Artificial Intelligence Biological and medical sciences Delayed-Action Preparations Excipients Female Fuzzy Logic General pharmacology Humans Intestinal Absorption Male Medical sciences Models, Biological Neuropharmacology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Suppositories Fuzzy system simulation Bioavailability Modeling Rectal administration layered excipient suppository modelling Paracetamol Absorption Analgesic Formulation Immediate release form Antipyretic Dosage form Mathematical model Pharmacokinetics Suppository Comparative study
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