ASYMPTOTIC AND NUMERICAL RESULTS FOR A MODEL OF SOLVENT-DEPENDENT DRUG DIFFUSION THROUGH POLYMERIC SPHERES

A model for drug diffusion from a spherical polymeric drug delivery device is considered. The model contains two key features. The first is that solvent diffuses into the polymer, which then transitions from a glassy to a rubbery state. The interface between the two states of polymer is modeled as a...

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Bibliographic Details

Published in:	SIAM journal on applied mathematics Vol. 71; no. 6; pp. 2287 - 2311
Main Authors:	MCCUE, SCOTT W., HSIEH, MIKE, MORONEY, TIMOTHY J., NELSON, MARK I.
Format:	Journal Article
Language:	English
Published:	Philadelphia Society for Industrial and Applied Mathematics 01-01-2011
Subjects:	Applied mathematics Diffusion coefficient Drug delivery systems Drug design Kinetics Mathematical models Mathematics Melting Polymers Solvents Special Section Spheres Supercooling Swelling
Online Access:	Get full text
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