Impact of moderate physical exercise--in comparison with dietary restrictions--on age-associated decline in cell-mediated immunity of Sprague-Dawley rats
Moderate physical exercise and dietary restriction have both been demonstrated to delay some of the adverse effects of aging. In order to elucidate similarities or dissimilarities in their mode of action on the aging immune system in a comparative setting, we examined significant parameters of cell-...
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| Published in: | Aging clinical and experimental research Vol. 18; no. 3; pp. 179 - 186 |
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| Abstract | Moderate physical exercise and dietary restriction have both been demonstrated to delay some of the adverse effects of aging. In order to elucidate similarities or dissimilarities in their mode of action on the aging immune system in a comparative setting, we examined significant parameters of cell-mediated immunity in Sprague- Dawley rats.
Male Sprague-Dawley rats, housed individually, were divided into four groups, living from 5 months (baseline group BL) up to 15, 19 and 23 months of age as follows: voluntary running in wheels (RW), food restricted by feeding to pair weight with RW animals (PW), forced running on treadmills (TM), and sedentary controls with ad libitum access to food (S1). White blood cell counts, capacity for lymphocyte proliferation in response to Concanavalin A, and interleukin-2 (IL-2) plasma concentrations were determined.
White blood cell counts and the cell numbers of lymphocytes, neutrophil and eosinophil granulocytes were significantly lower in the older RW and PW groups. We observed influences of forced exercise on lymphocyte proliferation: blastogenic reactivity was higher in TM animals compared with RW and PW animals at 23 months of age. Exclusively for RW animals, we found lower plasma concentrations of IL-2 at 23 months.
Our data support the idea that moderate physical exercise modulates age-associated decline in the cell-mediated immunity of old Sprague-Dawley rats significantly more than corresponding dietary restrictions. |
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| AbstractList | Moderate physical exercise and dietary restriction have both been demonstrated to delay some of the adverse effects of aging. In order to elucidate similarities or dissimilarities in their mode of action on the aging immune system in a comparative setting, we examined significant parameters of cell-mediated immunity in Sprague- Dawley rats.
Male Sprague-Dawley rats, housed individually, were divided into four groups, living from 5 months (baseline group BL) up to 15, 19 and 23 months of age as follows: voluntary running in wheels (RW), food restricted by feeding to pair weight with RW animals (PW), forced running on treadmills (TM), and sedentary controls with ad libitum access to food (S1). White blood cell counts, capacity for lymphocyte proliferation in response to Concanavalin A, and interleukin-2 (IL-2) plasma concentrations were determined.
White blood cell counts and the cell numbers of lymphocytes, neutrophil and eosinophil granulocytes were significantly lower in the older RW and PW groups. We observed influences of forced exercise on lymphocyte proliferation: blastogenic reactivity was higher in TM animals compared with RW and PW animals at 23 months of age. Exclusively for RW animals, we found lower plasma concentrations of IL-2 at 23 months.
Our data support the idea that moderate physical exercise modulates age-associated decline in the cell-mediated immunity of old Sprague-Dawley rats significantly more than corresponding dietary restrictions. Background and aims: Moderate physical exercise and dietary restriction have both been demonstrated to delay some of the adverse effects of aging. In order to elucidate similarities or dissimilarities in their mode of action on the aging immune system in a comparative setting, we examined significant parameters of cell-mediated immunity in Sprague- Dawley rats. Methods: Male Sprague-Dawley rats, housed individually, were divided into four groups, living from 5 months (baseline group BL) up to 15, 19 and 23 months of age as follows: voluntary running in wheels (RW), food restricted by feeding to pair weight with RW animals (PW), forced running on treadmills (TM), and sedentary controls with ad libitum access to food (S1). White blood cell counts, capacity for lymphocyte proliferation in response to Concanavalin A, and interleukin-2 (IL-2) plasma concentrations were determined. Results: White blood cell counts and the cell numbers of lymphocytes, neutrophil and eosinophil granulocytes were significantly lower in the older RW and PW groups. We observed influences of forced exercise on lymphocyte proliferation: blastogenic reactivity was higher in TM animals compared with RW and PW animals at 23 months of age. Exclusively for RW animals, we found lower plasma concentrations of IL-2 at 23 months. Conclusions: Our data support the idea that moderate physical exercise modulates age-associated decline in the cell-mediated immunity of old Sprague-Dawley rats significantly more than corresponding dietary restrictions. BACKGROUND AND AIMSModerate physical exercise and dietary restriction have both been demonstrated to delay some of the adverse effects of aging. In order to elucidate similarities or dissimilarities in their mode of action on the aging immune system in a comparative setting, we examined significant parameters of cell-mediated immunity in Sprague- Dawley rats. METHODSMale Sprague-Dawley rats, housed individually, were divided into four groups, living from 5 months (baseline group BL) up to 15, 19 and 23 months of age as follows: voluntary running in wheels (RW), food restricted by feeding to pair weight with RW animals (PW), forced running on treadmills (TM), and sedentary controls with ad libitum access to food (S1). White blood cell counts, capacity for lymphocyte proliferation in response to Concanavalin A, and interleukin-2 (IL-2) plasma concentrations were determined. RESULTSWhite blood cell counts and the cell numbers of lymphocytes, neutrophil and eosinophil granulocytes were significantly lower in the older RW and PW groups. We observed influences of forced exercise on lymphocyte proliferation: blastogenic reactivity was higher in TM animals compared with RW and PW animals at 23 months of age. Exclusively for RW animals, we found lower plasma concentrations of IL-2 at 23 months. CONCLUSIONSOur data support the idea that moderate physical exercise modulates age-associated decline in the cell-mediated immunity of old Sprague-Dawley rats significantly more than corresponding dietary restrictions. |
| Author | Strasser, Alois Viidik, Andrus Skalicky, Monika |
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J Appl Physiol contributor: fullname: I Nasrullah – volume: 51 start-page: 83 year: 2005 ident: BF03324646_CR19 publication-title: Gerontology doi: 10.1159/000082193 contributor: fullname: G Loupal – volume: 175 start-page: 51 year: 1997 ident: BF03324646_CR10 publication-title: Cell Immunol doi: 10.1006/cimm.1996.1040 contributor: fullname: GG Garcia – volume: 54 start-page: 771 year: 1993 ident: BF03324646_CR30 publication-title: Physiol Behav doi: 10.1016/0031-9384(93)90090-3 contributor: fullname: KJ Coleman – volume: 36 start-page: 1699 year: 2001 ident: BF03324646_CR17 publication-title: Exp Gerontol doi: 10.1016/S0531-5565(01)00145-0 contributor: fullname: E Narath – volume: 491 start-page: 114 year: 2001 ident: BF03324646_CR26 publication-title: FEBS Lett doi: 10.1016/S0014-5793(01)02184-6 contributor: fullname: MA Pahlavani – volume: 114 start-page: 1 year: 1988 ident: BF03324646_CR9 publication-title: Cell Immunol doi: 10.1016/0008-8749(88)90250-X contributor: fullname: ML Thoman – volume: 4 start-page: 8 year: 2004 ident: BF03324646_CR34 publication-title: BMC Geriatr doi: 10.1186/1471-2318-4-8 contributor: fullname: N Drela – volume: 9 start-page: 73 year: 1997 ident: BF03324646_CR2 publication-title: Aging Clin Exp Res doi: 10.1007/BF03340130 contributor: fullname: RJ McCarter – volume: 39 start-page: 1333 year: 2004 ident: BF03324646_CR18 publication-title: Exp Gerontol doi: 10.1016/j.exger.2004.06.014 contributor: fullname: M Novelli – volume: 19 start-page: 185 year: 1997 ident: BF03324646_CR22 publication-title: Immunopharmacol Immunotoxicol doi: 10.3109/08923979709007658 contributor: fullname: DK Flaherty – volume: 7 start-page: 40 year: 1995 ident: BF03324646_CR15 publication-title: Aging Clin Exp Res doi: 10.1007/BF03324291 contributor: fullname: DS Byun – volume: 27 start-page: 201 year: 1992 ident: BF03324646_CR32 publication-title: Exp Gerontol doi: 10.1016/0531-5565(92)90044-Z contributor: fullname: ML Riley-Roberts – volume: 91 start-page: 219 year: 1996 ident: BF03324646_CR12 publication-title: Mech Ag Dev doi: 10.1016/S0047-6374(96)01792-7 contributor: fullname: M Utsuyama – volume: 53 start-page: B330 year: 1998 ident: BF03324646_CR27 publication-title: J Gerontol doi: 10.1093/gerona/53A.5.B330 contributor: fullname: J Chen – volume: 93 start-page: 25 year: 1997 ident: BF03324646_CR16 publication-title: Mech Ageing Dev doi: 10.1016/S0047-6374(96)01808-8 contributor: fullname: CC Spaulding – volume: 279 start-page: R1321 year: 2000 ident: BF03324646_CR31 publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.2000.279.4.R1321 contributor: fullname: A Moraska – volume: 20 start-page: 109 year: 1999 ident: BF03324646_CR35 publication-title: Specific cellular immunity. Immunol Res doi: 10.1007/BF02786467 contributor: fullname: L Ginaldi – volume: 35 start-page: 348 year: 2003 ident: BF03324646_CR25 publication-title: Med Sci Sports Exerc doi: 10.1249/01.MSS.0000048861.57899.04 contributor: fullname: K Suzuki – volume: 70 start-page: 2535 year: 1991 ident: BF03324646_CR13 publication-title: J Appl Physiol doi: 10.1152/jappl.1991.70.6.2535 contributor: fullname: GD Tharp – volume: 10 start-page: 63 year: 1935 ident: BF03324646_CR4 publication-title: J Nutr doi: 10.1093/jn/10.1.63 contributor: fullname: CM McCay – volume: 9 start-page: 42 year: 1997 ident: BF03324646_CR6 publication-title: Aging Clin Exp Res doi: 10.1007/BF03340127 contributor: fullname: JT Venkatraman – volume: 80 start-page: 1799 year: 1996 ident: BF03324646_CR14 publication-title: J Appl Physiol doi: 10.1152/jappl.1996.80.5.1799 contributor: fullname: IH Jonsdottir – volume: 47 start-page: 181 year: 2000 ident: BF03324646_CR20 publication-title: J Vet Med doi: 10.1046/j.1439-0442.2000.00278.x contributor: fullname: A Strasser – start-page: 273 volume-title: Vienna Aging Series. Aspects of aging and disease year: 1994 ident: BF03324646_CR21 contributor: fullname: A Strasser – volume: 276 start-page: 205 year: 1996 ident: BF03324646_CR1 publication-title: JAMA doi: 10.1001/jama.1996.03540030039029 contributor: fullname: SN Blair – volume: 15 start-page: 154 year: 1994 ident: BF03324646_CR33 publication-title: Int J Sport Med doi: 10.1055/s-2007-1021131 contributor: fullname: RJ Shephard |
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| SubjectTerms | Age Aging - immunology Animals Caloric Restriction Exercise Immunity, Cellular - physiology Interleukin-2 - blood Leukocyte Count Male Physical Conditioning, Animal - physiology Rats Rats, Sprague-Dawley Rodents |
| Title | Impact of moderate physical exercise--in comparison with dietary restrictions--on age-associated decline in cell-mediated immunity of Sprague-Dawley rats |
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